NUPLAZID® (pimavanserin) logo - once daily - 34 mg capsules
NUPLAZID® (pimavanserin) logo - once daily - 34 mg capsules NUPLAZID® (pimavanserin) logo - once daily - 34 mg capsules

NUPLAZID® is an FDA-approved treatment for hallucinations and delusions associated with Parkinson's disease psychosis.

Hallucinations and delusions
are a treatable part of
Parkinson’s disease

Innovation mark

Hear from real people taking NUPLAZID

If you think you or your loved one may be experiencing PD-related hallucinations and delusions, talk to your doctor about a treatment option. Our Treatment Discussion Guide can help you prepare for the discussion.

These stories represent the experiences of people living with PD-related hallucinations and delusions. The opinions expressed are their own, and individual experiences may vary. Always speak with your healthcare provider.

Beverly & Bud’s story

Six years after being diagnosed with PD, Beverly started to experience hallucinations and delusions related to her Parkinson's. In this video, Beverly and her husband, Bud, share their story—from the first signs of Beverly’s symptoms to treatment with NUPLAZID.

John’s story

John is affected by hallucinations and delusions associated with PD psychosis. In this video, John speaks about the impact they have had on him, and his experience taking NUPLAZID to treat these symptoms.

Find out more about treatment with NUPLAZID

How NUPLAZID can help

NUPLAZID reduced the frequency and/or severity of Parkinson's disease
(PD)–related hallucinations and delusions

  • In the clinical trial, the majority of patients who took NUPLAZID experienced fewer and/or less severe hallucinations and delusions associated with PD psychosis when compared to placebo

  • Some patients did not experience any hallucinations or delusions at 6 weeks. Not everyone will respond to NUPLAZID. Individual results may vary

The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.

Descending bar chart icon and down arrow represents NUPLAZID® reducing hallucinations & delusions associated with PD psychosis

NUPLAZID had no effect on motor symptoms

  • In the clinical trial, NUPLAZID had no effect on motor symptoms compared with a placebo at 6 weeks
Icon showing the palm of the hand represents motor symptoms of PD

Clinical trial details

  • To test the efficacy of NUPLAZID, an FDA-accepted tool measured the changes in the frequency and/or severity of hallucinations and delusions associated with PD psychosis

  • The clinical trial included 199 adults (at least 40 years of age with an average age of 72 years) diagnosed with hallucinations and delusions associated with PD psychosis that was severe and frequent enough for treatment

  • Each person was assigned to 1 of 2 groups: those who received NUPLAZID 34 mg or those who received placebo. Results were reported at the end of 6 weeks

Efficacy icon shows capsule and labeled jar representing NUPLAZID®

NUPLAZID works around-the-clock to help reduce hallucinations and delusions associated with PD psychosis

  • The recommended dose of NUPLAZID is one 34 mg capsule, once daily by mouth, with or without food, around the same time every day, or as prescribed by your healthcare provider

  • It’s important to remember that everyone responds to medications differently, so it may take some time for NUPLAZID to start working

Around-the-clock icon representing how NUPLAZID® works around the clock to help reduce PD-related hallucinations and delusions

Continuing to take NUPLAZID as prescribed may help you see results

  • NUPLAZID may begin to reduce hallucinations and delusions as soon as 4 weeks, but it may take up to 6 weeks to feel the full effect

  • You should speak with your healthcare provider before you stop taking NUPLAZID

Calendar icon represents PD-related hallucinations and delusions over time and how NUPLAZID® treats PD-related hallucinations and delusions over time
Taking NUPLAZID

  • You can take NUPLAZID without adjusting doses of carbidopa/levodopa medicines

  • NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval

  • Tell your healthcare provider about any changes in the medicines you are taking. Some prescriptions or over-the-counter medicines may interact with NUPLAZID and should not be taken

Important Safety Information

Who should not take NUPLAZID?

  • Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath.
  • Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.

What other warnings should I know about NUPLAZID?

  • QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.

See below for additional Important Safety Information.

Icon of heartbeat rhythm line graph with red heart reflects potential serious side effects of NUPLAZID®, which can change your heart rhythm
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FAQs icon represents answers to FAQs about Parkinson’s disease–related hallucinations and delusions, and NUPLAZID® medication

Have questions about your treatment options? Bring the Treatment Discussion Guide to your next appointment

Download Treatment
Discussion Guide
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Personal 
Stories
Safety
 Information

IMPORTANT SAFETY INFORMATION and INDICATION

What is the most important information I should know about NUPLAZID?

  • Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

  • NUPLAZID is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.

Who should not take NUPLAZID?

  • Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath.
  • Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.

What other warnings should I know about NUPLAZID?

  • QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.

    Please also see What is the most important information I should know about NUPLAZID?

What medicine might interact with NUPLAZID?

  • Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first.

What are the common side effects of NUPLAZID?

  • The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088. You can also call Acadia Pharmaceuticals Inc. at 1‑844‑4ACADIA (1‑844‑422‑2342).

Indication

NUPLAZID is a prescription medicine used to treat hallucinations and delusions associated with Parkinson’s disease psychosis.

How should I take NUPLAZID?

The recommended dose of NUPLAZID is one 34 mg capsule once per day, taken by mouth, with or without food.

NUPLAZID is available as 34 mg capsules and 10 mg tablets.

Please read the full Prescribing Information, including Boxed WARNING.

See Safety Information
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Symfony Exception

Symfony Docs
Symfony Support

ErrorException

HTTP 500 Internal Server Error

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Exception

ErrorException

in vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php (line 175)
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  10.         if (!$profileIndexed) {
  11.             // Add to index
in vendor/symfony/http-kernel/Profiler/Profiler.php -> write (line 101)
  1.             if ($collector instanceof LateDataCollectorInterface) {
  2.                 $collector->lateCollect();
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  4.         }
  6.         if (!($ret = $this->storage->write($profile)) && null !== $this->logger) {
  7.             $this->logger->warning('Unable to store the profiler information.', ['configured_storage' => \get_class($this->storage)]);
  8.         }
  10.         return $ret;
  11.     }
in vendor/symfony/http-kernel/EventListener/ProfilerListener.php -> saveProfile (line 112)
  1.             }
  2.         }
  4.         // save profiles
  5.         foreach ($this->profiles as $request) {
  6.             $this->profiler->saveProfile($this->profiles[$request]);
  7.         }
  9.         $this->profiles = new \SplObjectStorage();
  10.         $this->parents = new \SplObjectStorage();
  11.     }
in vendor/symfony/event-dispatcher/Debug/WrappedListener.php -> onKernelTerminate (line 117)
  1.         $this->called = true;
  2.         $this->priority = $dispatcher->getListenerPriority($eventName, $this->listener);
  4.         $e = $this->stopwatch->start($this->name, 'event_listener');
  6.         ($this->optimizedListener ?? $this->listener)($event, $eventName, $dispatcher);
  8.         if ($e->isStarted()) {
  9.             $e->stop();
  10.         }
in vendor/symfony/event-dispatcher/EventDispatcher.php -> __invoke (line 230)
  2.         foreach ($listeners as $listener) {
  3.             if ($stoppable && $event->isPropagationStopped()) {
  4.                 break;
  5.             }
  6.             $listener($event, $eventName, $this);
  7.         }
  8.     }
  10.     /**
  11.      * Sorts the internal list of listeners for the given event by priority.
in vendor/symfony/event-dispatcher/EventDispatcher.php -> callListeners (line 59)
  1.         } else {
  2.             $listeners = $this->getListeners($eventName);
  3.         }
  5.         if ($listeners) {
  6.             $this->callListeners($listeners, $eventName, $event);
  7.         }
  9.         return $event;
  10.     }
in vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php -> dispatch (line 151)
  1.         try {
  2.             $this->beforeDispatch($eventName, $event);
  3.             try {
  4.                 $e = $this->stopwatch->start($eventName, 'section');
  5.                 try {
  6.                     $this->dispatcher->dispatch($event, $eventName);
  7.                 } finally {
  8.                     if ($e->isStarted()) {
  9.                         $e->stop();
  10.                     }
  11.                 }
in vendor/symfony/http-kernel/HttpKernel.php -> dispatch (line 99)
  1.     /**
  2.      * {@inheritdoc}
  3.      */
  4.     public function terminate(Request $request, Response $response)
  5.     {
  6.         $this->dispatcher->dispatch(new TerminateEvent($this, $request, $response), KernelEvents::TERMINATE);
  7.     }
  9.     /**
  10.      * @internal
  11.      */
in vendor/symfony/http-kernel/Kernel.php -> terminate (line 161)
  1.         if (false === $this->booted) {
  2.             return;
  3.         }
  5.         if ($this->getHttpKernel() instanceof TerminableInterface) {
  6.             $this->getHttpKernel()->terminate($request, $response);
  7.         }
  8.     }
  10.     /**
  11.      * {@inheritdoc}
Kernel->terminate(object(Request), object(Response)) in public/index.php (line 35)
  1.     $kernel = new CacheKernel($kernel);
  2. }
  3. $request = Request::createFromGlobals();
  4. $response = $kernel->handle($request);
  5. $response->send();
  6. $kernel->terminate($request, $response);

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    "exception": "N;"
}
INFO 09:28:17 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/23b9796d-03b2-41e3-8e4e-44192a131fc2?locale=en-US (0.015s)
DEBUG 09:28:17 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/23b9796d-03b2-41e3-8e4e-44192a131fc2?locale=en-US (0.015s) 
{
    "api": "DELIVERY",
    "duration": 0.015295982360839844,
    "request": "GET /spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/23b9796d-03b2-41e3-8e4e-44192a131fc2?locale=en-US HTTP/1.1\r\nHost: cdn.contentful.com\r\nX-Contentful-User-Agent: integration contentful.symfony/6.1.0; sdk contentful.php/6.0.5; platform PHP/7.3.27; os Linux;\r\nAccept: application/vnd.contentful.delivery.v1+json\r\nAccept-Encoding: gzip\r\nAuthorization: Bearer lRzj2SIrbl-UcukRbaRBW6TDRru28Z4mitiO4zneFcQ\r\n\r\n",
    "response": "HTTP/1.1 200 OK\r\nConnection: keep-alive\r\nContent-Length: 595\r\ncontent-type: application/vnd.contentful.delivery.v1+json\r\nx-contentful-ratelimit-second-limit: 150\r\ncf-environment-uuid: e892f65c-ca0b-48ab-aa26-6627f8bb1bc8\r\ncf-organization-id: 6AK7JXzYfDGtxR8WVj1mwu\r\netag: \"11543160015497312453\"\r\nx-content-type-options: nosniff\r\nserver: Contentful\r\nserver-timing: miss, origin;dur=34, total;dur=51\r\ncontentful-api: cda\r\ncache-control: s-maxage=2592000\r\nVia: 1.1 varnish, 1.1 varnish\r\nAccept-Ranges: bytes\r\nAge: 662299\r\nDate: Sat, 19 Sep 2026 09:28:17 GMT\r\nX-Served-By: cache-ewr-kewr1740032-EWR, cache-ewr-kewr1740032-EWR, cache-chi-kmdw8640098-CHI\r\nX-Cache-Hits: 1, 0\r\naccess-control-allow-headers: X-Contentful-Extensions-Sourcemap,X-Contentful-Personal-Intercept,accept,accept-language,authorization,cache-control,content-length,content-range,content-type,dnt,destination,expires,if-match,if-modified-since,if-none-match,keep-alive,last-modified,origin,pragma,range,user-agent,x-http-method-override,x-mx-reqtoken,x-requested-with,x-contentful-content-type,x-contentful-enable-alpha-feature,x-contentful-locale-based-publishing,x-contentful-organization,x-contentful-resource-resolution,x-contentful-skip-transformation,x-contentful-user-agent,x-contentful-version\r\naccess-control-allow-methods: GET,HEAD,OPTIONS\r\naccess-control-allow-origin: *\r\naccess-control-max-age: 86400\r\naccess-control-expose-headers: etag\r\nstrict-transport-security: max-age=15768000\r\nX-Cache: HIT\r\nx-contentful-request-id: 4a9107fd-1a23-4d5d-9103-8c90fe528e2e\r\n\r\n{\"metadata\":{\"tags\":[],\"concepts\":[]},\"sys\":{\"space\":{\"sys\":{\"type\":\"Link\",\"linkType\":\"Space\",\"id\":\"5op9sxpwqnmz\"}},\"id\":\"23b9796d-03b2-41e3-8e4e-44192a131fc2\",\"type\":\"Entry\",\"createdAt\":\"2024-10-24T15:05:16.846Z\",\"updatedAt\":\"2024-10-24T15:05:16.846Z\",\"environment\":{\"sys\":{\"id\":\"2.6.2_remove-opt-in\",\"type\":\"Link\",\"linkType\":\"Environment\"}},\"publishedVersion\":1,\"revision\":1,\"contentType\":{\"sys\":{\"type\":\"Link\",\"linkType\":\"ContentType\",\"id\":\"contentItem\"}},\"locale\":\"en-US\"},\"fields\":{\"page\":\"404-page-not-found\",\"content\":\"<p>12830 El Camino Real, Suite 400<br />\\nSan Diego, CA 92130</p>\"}}\n",
    "exception": "N;"
}
INFO 09:28:17 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/fbccc97f-4a4c-4fe8-beaa-ca8d58c43a0a?locale=en-US (0.016s)
DEBUG 09:28:17 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/fbccc97f-4a4c-4fe8-beaa-ca8d58c43a0a?locale=en-US (0.016s) 
{
    "api": "DELIVERY",
    "duration": 0.016145944595336914,
    "request": "GET /spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/fbccc97f-4a4c-4fe8-beaa-ca8d58c43a0a?locale=en-US HTTP/1.1\r\nHost: cdn.contentful.com\r\nX-Contentful-User-Agent: integration contentful.symfony/6.1.0; sdk contentful.php/6.0.5; platform PHP/7.3.27; os Linux;\r\nAccept: application/vnd.contentful.delivery.v1+json\r\nAccept-Encoding: gzip\r\nAuthorization: Bearer lRzj2SIrbl-UcukRbaRBW6TDRru28Z4mitiO4zneFcQ\r\n\r\n",
    "response": "HTTP/1.1 200 OK\r\nConnection: keep-alive\r\nContent-Length: 592\r\ncontent-type: application/vnd.contentful.delivery.v1+json\r\nx-contentful-ratelimit-second-limit: 150\r\ncf-environment-uuid: e892f65c-ca0b-48ab-aa26-6627f8bb1bc8\r\ncf-organization-id: 6AK7JXzYfDGtxR8WVj1mwu\r\netag: \"12939619960788279001\"\r\nx-content-type-options: nosniff\r\nserver: Contentful\r\nserver-timing: miss, origin;dur=37, total;dur=53\r\ncontentful-api: cda\r\ncache-control: s-maxage=2592000\r\nVia: 1.1 varnish, 1.1 varnish\r\nAccept-Ranges: bytes\r\nAge: 662300\r\nDate: Sat, 19 Sep 2026 09:28:17 GMT\r\nX-Served-By: cache-ewr-kewr1740027-EWR, cache-ewr-kewr1740027-EWR, cache-chi-kmdw8640098-CHI\r\nX-Cache-Hits: 1, 0\r\naccess-control-allow-headers: X-Contentful-Extensions-Sourcemap,X-Contentful-Personal-Intercept,accept,accept-language,authorization,cache-control,content-length,content-range,content-type,dnt,destination,expires,if-match,if-modified-since,if-none-match,keep-alive,last-modified,origin,pragma,range,user-agent,x-http-method-override,x-mx-reqtoken,x-requested-with,x-contentful-content-type,x-contentful-enable-alpha-feature,x-contentful-locale-based-publishing,x-contentful-organization,x-contentful-resource-resolution,x-contentful-skip-transformation,x-contentful-user-agent,x-contentful-version\r\naccess-control-allow-methods: GET,HEAD,OPTIONS\r\naccess-control-allow-origin: *\r\naccess-control-max-age: 86400\r\naccess-control-expose-headers: etag\r\nstrict-transport-security: max-age=15768000\r\nX-Cache: HIT\r\nx-contentful-request-id: 5a50c6f1-928d-4a74-a84e-664f9175b72a\r\n\r\n{\"metadata\":{\"tags\":[],\"concepts\":[]},\"sys\":{\"space\":{\"sys\":{\"type\":\"Link\",\"linkType\":\"Space\",\"id\":\"5op9sxpwqnmz\"}},\"id\":\"fbccc97f-4a4c-4fe8-beaa-ca8d58c43a0a\",\"type\":\"Entry\",\"createdAt\":\"2024-10-24T15:05:17.222Z\",\"updatedAt\":\"2024-10-24T15:05:17.222Z\",\"environment\":{\"sys\":{\"id\":\"2.6.2_remove-opt-in\",\"type\":\"Link\",\"linkType\":\"Environment\"}},\"publishedVersion\":1,\"revision\":1,\"contentType\":{\"sys\":{\"type\":\"Link\",\"linkType\":\"ContentType\",\"id\":\"contentItem\"}},\"locale\":\"en-US\"},\"fields\":{\"page\":\"404-page-not-found\",\"content\":\"<a href=\\\"/safety-information\\\">**See Safety Information**</a>\"}}\n",
    "exception": "N;"
}
INFO 09:28:17 security Populated the TokenStorage with an anonymous Token.
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Nelmio\CorsBundle\EventListener\CorsListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Nelmio\\CorsBundle\\EventListener\\CorsListener::onKernelResponse"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Nelmio\CorsBundle\EventListener\CacheableResponseVaryListener::onResponse". 
{
    "event": "kernel.response",
    "listener": "Nelmio\\CorsBundle\\EventListener\\CacheableResponseVaryListener::onResponse"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ResponseListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ResponseListener::onKernelResponse"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\DataCollector\\RequestDataCollector::onKernelResponse"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Symfony\Component\WebLink\EventListener\AddLinkHeaderListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\WebLink\\EventListener\\AddLinkHeaderListener::onKernelResponse"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\HttpCacheListener::onKernelResponse"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Symfony\Component\Security\Http\RememberMe\ResponseListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\Security\\Http\\RememberMe\\ResponseListener::onKernelResponse"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ProfilerListener::onKernelResponse"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ErrorListener::removeCspHeader". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ErrorListener::removeCspHeader"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Symfony\Bundle\WebProfilerBundle\EventListener\WebDebugToolbarListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Bundle\\WebProfilerBundle\\EventListener\\WebDebugToolbarListener::onKernelResponse"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onKernelResponse"
}
DEBUG 09:28:17 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\StreamedResponseListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\StreamedResponseListener::onKernelResponse"
}
DEBUG 09:28:17 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::onKernelFinishRequest"
}
DEBUG 09:28:17 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onFinishRequest"
}
DEBUG 09:28:17 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\RouterListener::onKernelFinishRequest"
}
DEBUG 09:28:17 event Notified event "kernel.finish_request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::onKernelFinishRequest"
}
DEBUG 09:28:17 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleAwareListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleAwareListener::onKernelFinishRequest"
}
DEBUG 09:28:17 event Notified event "kernel.terminate" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelTerminate". 
{
    "event": "kernel.terminate",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ProfilerListener::onKernelTerminate"
}
WARNING 09:28:17 php Uncaught Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/64/43/744364): failed to open stream: operation failed 
{
    "exception": {}
}
CRITICAL 09:28:17 request Uncaught PHP Exception ErrorException: "Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/64/43/744364): failed to open stream: operation failed" at /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php line 175 
{
    "exception": {}
}
DEBUG 09:28:17 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::configure". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\DebugHandlersListener::configure"
}
DEBUG 09:28:17 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ValidateRequestListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ValidateRequestListener::onKernelRequest"
}
DEBUG 09:28:17 event Notified event "kernel.request" to listener "Nelmio\CorsBundle\EventListener\CorsListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Nelmio\\CorsBundle\\EventListener\\CorsListener::onKernelRequest"
}
DEBUG 09:28:17 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onKernelRequest"
}
DEBUG 09:28:17 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::setDefaultLocale". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::setDefaultLocale"
}
DEBUG 09:28:17 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\RouterListener::onKernelRequest"
}
DEBUG 09:28:17 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::onKernelRequest"
}
DEBUG 09:28:17 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleAwareListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleAwareListener::onKernelRequest"
}
DEBUG 09:28:17 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::configureLogoutUrlGenerator". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::configureLogoutUrlGenerator"
}
DEBUG 09:28:17 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::onKernelRequest"
}
DEBUG 09:28:17 event Notified event "kernel.controller" to listener "Symfony\Bundle\FrameworkBundle\DataCollector\RouterDataCollector::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Symfony\\Bundle\\FrameworkBundle\\DataCollector\\RouterDataCollector::onKernelController"
}
DEBUG 09:28:17 event Notified event "kernel.controller" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Symfony\\Component\\HttpKernel\\DataCollector\\RequestDataCollector::onKernelController"
}
DEBUG 09:28:17 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ControllerListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\ControllerListener::onKernelController"
}
DEBUG 09:28:17 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ParamConverterListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\ParamConverterListener::onKernelController"
}
DEBUG 09:28:17 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\HttpCacheListener::onKernelController"
}
DEBUG 09:28:17 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\TemplateListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\TemplateListener::onKernelController"
}
DEBUG 09:28:17 event Notified event "kernel.controller_arguments" to listener "Symfony\Component\HttpKernel\EventListener\ErrorListener::onControllerArguments". 
{
    "event": "kernel.controller_arguments",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ErrorListener::onControllerArguments"
}
DEBUG 09:28:17 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\SecurityListener::onKernelControllerArguments". 
{
    "event": "kernel.controller_arguments",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\SecurityListener::onKernelControllerArguments"
}
DEBUG 09:28:17 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\IsGrantedListener::onKernelControllerArguments". 
{
    "event": "kernel.controller_arguments",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\IsGrantedListener::onKernelControllerArguments"
}

Stack Trace

ErrorException 

ErrorException:
Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/64/43/744364): failed to open stream: operation failed

  at vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php:175
  at Symfony\Component\HttpKernel\Profiler\FileProfilerStorage->write(object(Profile))
     (vendor/symfony/http-kernel/Profiler/Profiler.php:101)
  at Symfony\Component\HttpKernel\Profiler\Profiler->saveProfile(object(Profile))
     (vendor/symfony/http-kernel/EventListener/ProfilerListener.php:112)
  at Symfony\Component\HttpKernel\EventListener\ProfilerListener->onKernelTerminate(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (vendor/symfony/event-dispatcher/Debug/WrappedListener.php:117)
  at Symfony\Component\EventDispatcher\Debug\WrappedListener->__invoke(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (vendor/symfony/event-dispatcher/EventDispatcher.php:230)
  at Symfony\Component\EventDispatcher\EventDispatcher->callListeners(array(object(WrappedListener)), 'kernel.terminate', object(TerminateEvent))
     (vendor/symfony/event-dispatcher/EventDispatcher.php:59)
  at Symfony\Component\EventDispatcher\EventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php:151)
  at Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (vendor/symfony/http-kernel/HttpKernel.php:99)
  at Symfony\Component\HttpKernel\HttpKernel->terminate(object(Request), object(Response))
     (vendor/symfony/http-kernel/Kernel.php:161)
  at Symfony\Component\HttpKernel\Kernel->terminate(object(Request), object(Response))
     (public/index.php:35)
Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/36/66/9c6636): failed to open stream: operation failed (500 Internal Server Error)

Symfony Exception

Symfony Docs
Symfony Support

ErrorException

HTTP 500 Internal Server Error

Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/36/66/9c6636): failed to open stream: operation failed

Exception

ErrorException

in /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php (line 175)
  1.         if (\function_exists('gzcompress')) {
  2.             $file = 'compress.zlib://'.$file;
  3.             stream_context_set_option($context, 'zlib', 'level', 3);
  4.         }
  6.         if (false === file_put_contents($file, serialize($data), 0, $context)) {
  7.             return false;
  8.         }
  10.         if (!$profileIndexed) {
  11.             // Add to index
in /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/Profiler.php -> write (line 101)
  1.             if ($collector instanceof LateDataCollectorInterface) {
  2.                 $collector->lateCollect();
  3.             }
  4.         }
  6.         if (!($ret = $this->storage->write($profile)) && null !== $this->logger) {
  7.             $this->logger->warning('Unable to store the profiler information.', ['configured_storage' => \get_class($this->storage)]);
  8.         }
  10.         return $ret;
  11.     }
in /home/site/wwwroot/vendor/symfony/http-kernel/EventListener/ProfilerListener.php -> saveProfile (line 112)
  1.             }
  2.         }
  4.         // save profiles
  5.         foreach ($this->profiles as $request) {
  6.             $this->profiler->saveProfile($this->profiles[$request]);
  7.         }
  9.         $this->profiles = new \SplObjectStorage();
  10.         $this->parents = new \SplObjectStorage();
  11.     }
in /home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/WrappedListener.php -> onKernelTerminate (line 117)
  1.         $this->called = true;
  2.         $this->priority = $dispatcher->getListenerPriority($eventName, $this->listener);
  4.         $e = $this->stopwatch->start($this->name, 'event_listener');
  6.         ($this->optimizedListener ?? $this->listener)($event, $eventName, $dispatcher);
  8.         if ($e->isStarted()) {
  9.             $e->stop();
  10.         }
in /home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php -> __invoke (line 230)
  2.         foreach ($listeners as $listener) {
  3.             if ($stoppable && $event->isPropagationStopped()) {
  4.                 break;
  5.             }
  6.             $listener($event, $eventName, $this);
  7.         }
  8.     }
  10.     /**
  11.      * Sorts the internal list of listeners for the given event by priority.
in /home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php -> callListeners (line 59)
  1.         } else {
  2.             $listeners = $this->getListeners($eventName);
  3.         }
  5.         if ($listeners) {
  6.             $this->callListeners($listeners, $eventName, $event);
  7.         }
  9.         return $event;
  10.     }
in /home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php -> dispatch (line 151)
  1.         try {
  2.             $this->beforeDispatch($eventName, $event);
  3.             try {
  4.                 $e = $this->stopwatch->start($eventName, 'section');
  5.                 try {
  6.                     $this->dispatcher->dispatch($event, $eventName);
  7.                 } finally {
  8.                     if ($e->isStarted()) {
  9.                         $e->stop();
  10.                     }
  11.                 }
in /home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php -> dispatch (line 99)
  1.     /**
  2.      * {@inheritdoc}
  3.      */
  4.     public function terminate(Request $request, Response $response)
  5.     {
  6.         $this->dispatcher->dispatch(new TerminateEvent($this, $request, $response), KernelEvents::TERMINATE);
  7.     }
  9.     /**
  10.      * @internal
  11.      */
in /home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php -> terminate (line 116)
  1.         $response = $this->handleThrowable($exception, $request, self::MASTER_REQUEST);
  3.         $response->sendHeaders();
  4.         $response->sendContent();
  6.         $this->terminate($request, $response);
  7.     }
  9.     /**
  10.      * Handles a request to convert it to a response.
  11.      *
in /home/site/wwwroot/vendor/symfony/http-kernel/EventListener/DebugHandlersListener.php -> terminateWithException (line 118)
  1.                         if ($hasRun) {
  2.                             throw $e;
  3.                         }
  5.                         $hasRun = true;
  6.                         $kernel->terminateWithException($e, $request);
  7.                     };
  8.                 }
  9.             } elseif ($event instanceof ConsoleEvent && $app = $event->getCommand()->getApplication()) {
  10.                 $output = $event->getOutput();
  11.                 if ($output instanceof ConsoleOutputInterface) {
in /home/site/wwwroot/vendor/symfony/error-handler/ErrorHandler.php :: Symfony\Component\HttpKernel\EventListener\{closure} (line 594)
  1.             $this->exceptionHandler = null;
  2.         }
  4.         try {
  5.             if (null !== $exceptionHandler) {
  6.                 return $exceptionHandler($exception);
  7.             }
  8.             $handlerException = $handlerException ?: $exception;
  9.         } catch (\Throwable $handlerException) {
  10.         }
  11.         if ($exception === $handlerException && null === $this->exceptionHandler) {
ErrorHandler->handleException(object(ErrorException))

Stack Trace

ErrorException 

ErrorException:
Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/36/66/9c6636): failed to open stream: operation failed

  at /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php:175
  at Symfony\Component\HttpKernel\Profiler\FileProfilerStorage->write(object(Profile))
     (/home/site/wwwroot/vendor/symfony/http-kernel/Profiler/Profiler.php:101)
  at Symfony\Component\HttpKernel\Profiler\Profiler->saveProfile(object(Profile))
     (/home/site/wwwroot/vendor/symfony/http-kernel/EventListener/ProfilerListener.php:112)
  at Symfony\Component\HttpKernel\EventListener\ProfilerListener->onKernelTerminate(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/WrappedListener.php:117)
  at Symfony\Component\EventDispatcher\Debug\WrappedListener->__invoke(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php:230)
  at Symfony\Component\EventDispatcher\EventDispatcher->callListeners(array(object(WrappedListener)), 'kernel.terminate', object(TerminateEvent))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php:59)
  at Symfony\Component\EventDispatcher\EventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php:151)
  at Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (/home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php:99)
  at Symfony\Component\HttpKernel\HttpKernel->terminate(object(Request), object(Response))
     (/home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php:116)
  at Symfony\Component\HttpKernel\HttpKernel->terminateWithException(object(ErrorException), object(Request))
     (/home/site/wwwroot/vendor/symfony/http-kernel/EventListener/DebugHandlersListener.php:118)
  at Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::Symfony\Component\HttpKernel\EventListener\{closure}(object(ErrorException))
     (/home/site/wwwroot/vendor/symfony/error-handler/ErrorHandler.php:594)
  at Symfony\Component\ErrorHandler\ErrorHandler->handleException(object(ErrorException))