NUPLAZID® is an FDA-approved treatment for hallucinations and delusions associated with Parkinson's disease psychosis.

Frequently asked questions

Find answers to frequently asked questions about Parkinson’s disease–related hallucinations and delusions and NUPLAZID.

Are hallucinations and delusions common in people with PD?

  • A hallucination means seeing, hearing, or experiencing things that others don’t

  • A delusion means believing things that aren’t true

  • Hallucinations may be described as:

    • Seeing things that others don’t, such as people, either living or deceased, animals, or objects

    • Hearing things that others don’t, such as hearing sounds, music, or voices

    • Smelling things that aren't there, like unusual odors

    • Feeling something that isn't there, like something touching or moving on the skin

    • Tasting something that isn't there, like experiencing an unusual taste in the mouth

  • Delusions may be described as:

    • Paranoia, such as believing people are talking to you or trying to access your money

    • False beliefs, such as fears of your loved ones stealing from you, or loved ones putting you in harm's way

    • Jealousy, such as believing a significant other is having an affair

    • Beliefs that insignificant remarks or statements refer to you (eg, walking into a room of people laughing and assuming they are laughing at you)

  • Hallucinations and delusions are the most common symptoms of psychosis associated with PD
  • Currently there is no clear understanding of the exact cause of PD–related hallucinations and delusions

  • However, these symptoms are thought to be caused by the following:

    • A side effect of dopamine therapy. Hallucinations and delusions may be a side effect of common PD medications (called dopaminergic therapies). These medications increase dopamine levels in the brain, helping improve motor symptoms in patients with PD. However, increasing dopamine levels may also cause changes that lead to hallucinations and delusions

    • The natural progression of Parkinson’s disease. Hallucinations and delusions may be caused by changes in the brain that occur naturally as PD progresses—regardless of whether or not you take any medications to increase your dopamine levels

  • PD–related hallucinations and delusions typically occur in the later stages of PD, 10 or more years after initial diagnosis
  • It’s important to speak to a healthcare provider if you or your loved one think you may be experiencing hallucinations or delusions

  • PD–related hallucinations and delusions may get worse over time, and people who experience these symptoms may not have the ability to identify whether or not what they're experiencing is real

About NUPLAZID

What is NUPLAZID?

  • NUPLAZID is a prescription medicine used to treat hallucinations (such as seeing, hearing, or experiencing things that others don't) and delusions (such as believing things that are not true) associated with Parkinson’s disease psychosis
  • Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

  • NUPLAZID is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.

For additional safety information, see Safety page.

  • NUPLAZID may help to reduce the frequency and/or the severity of hallucinations and delusions associated with Parkinson's disease psychosis. Individual results may vary
  • Speak to your doctor to learn if NUPLAZID is right for you. NUPLAZID may help to reduce the frequency and/or the severity of hallucinations and delusions associated with Parkinson's disease psychosis. Individual results may vary
  • In the clinical trial, the majority of patients who took NUPLAZID experienced fewer and/or less severe hallucinations and delusions when compared to placebo. And some patients did not experience any hallucinations or delusions at 6 weeks. Not everyone will respond to NUPLAZID. Individual results may vary

  • NUPLAZID may begin to reduce hallucinations and delusions as soon as 4 weeks, but it may take up to 6 weeks to feel the full effect. You should speak with your healthcare provider before you stop taking NUPLAZID

See more about the trial.

  • In the clinical trial, NUPLAZID had no effect on motor symptoms compared with a placebo at 6 weeks
  • It is unclear how NUPLAZID actually works

  • NUPLAZID is thought to work by blocking certain receptors associated with hallucinations and delusions

  • NUPLAZID was approved by the FDA in 2016
  • Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath. Speak with your doctor to find out if NUPLAZID is right for you

Taking NUPLAZID

How do I take NUPLAZID?

  • The recommended dose of NUPLAZID is one 34 mg capsule, once daily by mouth, with or without food, taken around the same time every day, or as prescribed by your healthcare provider
  • NUPLAZID can be taken without adjusting carbidopa/levodopa medications. Some medicines should not be taken with NUPLAZID. Tell your healthcare provider about all of the medicines you are taking.

    Learn more about taking NUPLAZID
  • NUPLAZID may begin to reduce hallucinations and delusions as soon as 4 weeks, but it may take up to 6 weeks to feel the full effect. You should speak with your healthcare provider before you stop taking NUPLAZID
  • Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first
  • QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken

  • Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat

For additional safety information, see Safety page.

The common side effects of NUPLAZID include

  • Swelling in the legs or arms
  • Nausea
  • Confusion
  • Hallucination
  • Constipation
  • Changes to normal walking

These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider or pharmacist about this medicine.

Getting NUPLAZID

How do I get NUPLAZID?

  • Acadia Connect® can coordinate with you and the pharmacy filling the prescription to help get the medicine delivered wherever is most convenient to you

    Learn more about Acadia Connect
  • There are options available that may help you cover the cost of NUPLAZID. Visit Acadia Connect to learn more
Icon of person wearing a headset to represent visiting the Acadia Connect website for product or financial support questions

Learn about support for getting started on NUPLAZID

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Get more information about PD-related hallucinations and delusions

IMPORTANT SAFETY INFORMATION and INDICATION

What is the most important information I should know about NUPLAZID?

  • Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

  • NUPLAZID is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.

Who should not take NUPLAZID?

  • Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath.
  • Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.

What other warnings should I know about NUPLAZID?

  • QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.

    Please also see What is the most important information I should know about NUPLAZID?

What medicine might interact with NUPLAZID?

  • Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first.

What are the common side effects of NUPLAZID?

  • The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088. You can also call Acadia Pharmaceuticals Inc. at 1‑844‑4ACADIA (1‑844‑422‑2342).

Indication

NUPLAZID is a prescription medicine used to treat hallucinations and delusions associated with Parkinson’s disease psychosis.

How should I take NUPLAZID?

The recommended dose of NUPLAZID is one 34 mg capsule once per day, taken by mouth, with or without food.

NUPLAZID is available as 34 mg capsules and 10 mg tablets.

Please read the full Prescribing Information, including Boxed WARNING.

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Symfony Exception

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INFO 00:16:31 security Populated the TokenStorage with an anonymous Token.
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DEBUG 00:16:31 event Notified event "kernel.response" to listener "Nelmio\CorsBundle\EventListener\CacheableResponseVaryListener::onResponse".
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DEBUG 00:16:31 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ResponseListener::onKernelResponse".
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DEBUG 00:16:31 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelResponse".
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DEBUG 00:16:31 event Notified event "kernel.response" to listener "Symfony\Component\WebLink\EventListener\AddLinkHeaderListener::onKernelResponse".
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DEBUG 00:16:31 event Notified event "kernel.response" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelResponse".
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DEBUG 00:16:31 event Notified event "kernel.response" to listener "Symfony\Component\Security\Http\RememberMe\ResponseListener::onKernelResponse".
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DEBUG 00:16:31 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelResponse".
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DEBUG 00:16:31 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ErrorListener::removeCspHeader".
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DEBUG 00:16:31 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onKernelResponse".
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DEBUG 00:16:31 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\StreamedResponseListener::onKernelResponse".
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DEBUG 00:16:31 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelFinishRequest".
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DEBUG 00:16:31 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onFinishRequest".
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    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onFinishRequest"
}
DEBUG 00:16:31 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelFinishRequest".
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\RouterListener::onKernelFinishRequest"
}
DEBUG 00:16:31 event Notified event "kernel.finish_request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::onKernelFinishRequest".
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::onKernelFinishRequest"
}
DEBUG 00:16:31 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleAwareListener::onKernelFinishRequest".
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleAwareListener::onKernelFinishRequest"
}
DEBUG 00:16:32 event Notified event "kernel.terminate" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelTerminate".
{
    "event": "kernel.terminate",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ProfilerListener::onKernelTerminate"
}
WARNING 00:16:32 php Uncaught Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/33/34/7e3433): failed to open stream: operation failed
{
    "exception": {}
}
CRITICAL 00:16:32 request Uncaught PHP Exception ErrorException: "Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/33/34/7e3433): failed to open stream: operation failed" at /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php line 175
{
    "exception": {}
}
DEBUG 00:16:32 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::configure".
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\DebugHandlersListener::configure"
}
DEBUG 00:16:32 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ValidateRequestListener::onKernelRequest".
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ValidateRequestListener::onKernelRequest"
}
DEBUG 00:16:32 event Notified event "kernel.request" to listener "Nelmio\CorsBundle\EventListener\CorsListener::onKernelRequest".
{
    "event": "kernel.request",
    "listener": "Nelmio\\CorsBundle\\EventListener\\CorsListener::onKernelRequest"
}
DEBUG 00:16:32 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onKernelRequest".
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onKernelRequest"
}
DEBUG 00:16:32 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::setDefaultLocale".
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::setDefaultLocale"
}
DEBUG 00:16:32 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelRequest".
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\RouterListener::onKernelRequest"
}
DEBUG 00:16:32 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelRequest".
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::onKernelRequest"
}
DEBUG 00:16:32 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleAwareListener::onKernelRequest".
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleAwareListener::onKernelRequest"
}
DEBUG 00:16:32 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::configureLogoutUrlGenerator".
{
    "event": "kernel.request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::configureLogoutUrlGenerator"
}
DEBUG 00:16:32 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::onKernelRequest".
{
    "event": "kernel.request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::onKernelRequest"
}
DEBUG 00:16:32 event Notified event "kernel.controller" to listener "Symfony\Bundle\FrameworkBundle\DataCollector\RouterDataCollector::onKernelController".
{
    "event": "kernel.controller",
    "listener": "Symfony\\Bundle\\FrameworkBundle\\DataCollector\\RouterDataCollector::onKernelController"
}
DEBUG 00:16:32 event Notified event "kernel.controller" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelController".
{
    "event": "kernel.controller",
    "listener": "Symfony\\Component\\HttpKernel\\DataCollector\\RequestDataCollector::onKernelController"
}
DEBUG 00:16:32 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ControllerListener::onKernelController".
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\ControllerListener::onKernelController"
}
DEBUG 00:16:32 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ParamConverterListener::onKernelController".
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\ParamConverterListener::onKernelController"
}
DEBUG 00:16:32 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelController".
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\HttpCacheListener::onKernelController"
}
DEBUG 00:16:32 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\TemplateListener::onKernelController".
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\TemplateListener::onKernelController"
}
DEBUG 00:16:32 event Notified event "kernel.controller_arguments" to listener "Symfony\Component\HttpKernel\EventListener\ErrorListener::onControllerArguments".
{
    "event": "kernel.controller_arguments",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ErrorListener::onControllerArguments"
}
DEBUG 00:16:32 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\SecurityListener::onKernelControllerArguments".
{
    "event": "kernel.controller_arguments",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\SecurityListener::onKernelControllerArguments"
}
DEBUG 00:16:32 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\IsGrantedListener::onKernelControllerArguments".
{
    "event": "kernel.controller_arguments",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\IsGrantedListener::onKernelControllerArguments"
}

Stack Trace

ErrorException

ErrorException:
Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/33/34/7e3433): failed to open stream: operation failed

  at vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php:175
  at Symfony\Component\HttpKernel\Profiler\FileProfilerStorage->write(object(Profile))
     (vendor/symfony/http-kernel/Profiler/Profiler.php:101)
  at Symfony\Component\HttpKernel\Profiler\Profiler->saveProfile(object(Profile))
     (vendor/symfony/http-kernel/EventListener/ProfilerListener.php:112)
  at Symfony\Component\HttpKernel\EventListener\ProfilerListener->onKernelTerminate(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (vendor/symfony/event-dispatcher/Debug/WrappedListener.php:117)
  at Symfony\Component\EventDispatcher\Debug\WrappedListener->__invoke(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (vendor/symfony/event-dispatcher/EventDispatcher.php:230)
  at Symfony\Component\EventDispatcher\EventDispatcher->callListeners(array(object(WrappedListener)), 'kernel.terminate', object(TerminateEvent))
     (vendor/symfony/event-dispatcher/EventDispatcher.php:59)
  at Symfony\Component\EventDispatcher\EventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php:151)
  at Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (vendor/symfony/http-kernel/HttpKernel.php:99)
  at Symfony\Component\HttpKernel\HttpKernel->terminate(object(Request), object(Response))
     (vendor/symfony/http-kernel/Kernel.php:161)
  at Symfony\Component\HttpKernel\Kernel->terminate(object(Request), object(Response))
     (public/index.php:35)                
Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/e4/7f/0b7fe4): failed to open stream: operation failed (500 Internal Server Error)

Symfony Exception

ErrorException

HTTP 500 Internal Server Error

Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/e4/7f/0b7fe4): failed to open stream: operation failed

Exception

ErrorException

  1.         if (\function_exists('gzcompress')) {
  2.             $file 'compress.zlib://'.$file;
  3.             stream_context_set_option($context'zlib''level'3);
  4.         }
  5.         if (false === file_put_contents($fileserialize($data), 0$context)) {
  6.             return false;
  7.         }
  8.         if (!$profileIndexed) {
  9.             // Add to index
  1.             if ($collector instanceof LateDataCollectorInterface) {
  2.                 $collector->lateCollect();
  3.             }
  4.         }
  5.         if (!($ret $this->storage->write($profile)) && null !== $this->logger) {
  6.             $this->logger->warning('Unable to store the profiler information.', ['configured_storage' => \get_class($this->storage)]);
  7.         }
  8.         return $ret;
  9.     }
  1.             }
  2.         }
  3.         // save profiles
  4.         foreach ($this->profiles as $request) {
  5.             $this->profiler->saveProfile($this->profiles[$request]);
  6.         }
  7.         $this->profiles = new \SplObjectStorage();
  8.         $this->parents = new \SplObjectStorage();
  9.     }
  1.         $this->called true;
  2.         $this->priority $dispatcher->getListenerPriority($eventName$this->listener);
  3.         $e $this->stopwatch->start($this->name'event_listener');
  4.         ($this->optimizedListener ?? $this->listener)($event$eventName$dispatcher);
  5.         if ($e->isStarted()) {
  6.             $e->stop();
  7.         }
  1.         foreach ($listeners as $listener) {
  2.             if ($stoppable && $event->isPropagationStopped()) {
  3.                 break;
  4.             }
  5.             $listener($event$eventName$this);
  6.         }
  7.     }
  8.     /**
  9.      * Sorts the internal list of listeners for the given event by priority.
  1.         } else {
  2.             $listeners $this->getListeners($eventName);
  3.         }
  4.         if ($listeners) {
  5.             $this->callListeners($listeners$eventName$event);
  6.         }
  7.         return $event;
  8.     }
  1.         try {
  2.             $this->beforeDispatch($eventName$event);
  3.             try {
  4.                 $e $this->stopwatch->start($eventName'section');
  5.                 try {
  6.                     $this->dispatcher->dispatch($event$eventName);
  7.                 } finally {
  8.                     if ($e->isStarted()) {
  9.                         $e->stop();
  10.                     }
  11.                 }
  1.     /**
  2.      * {@inheritdoc}
  3.      */
  4.     public function terminate(Request $requestResponse $response)
  5.     {
  6.         $this->dispatcher->dispatch(new TerminateEvent($this$request$response), KernelEvents::TERMINATE);
  7.     }
  8.     /**
  9.      * @internal
  10.      */
  1.         $response $this->handleThrowable($exception$requestself::MASTER_REQUEST);
  2.         $response->sendHeaders();
  3.         $response->sendContent();
  4.         $this->terminate($request$response);
  5.     }
  6.     /**
  7.      * Handles a request to convert it to a response.
  8.      *
  1.                         if ($hasRun) {
  2.                             throw $e;
  3.                         }
  4.                         $hasRun true;
  5.                         $kernel->terminateWithException($e$request);
  6.                     };
  7.                 }
  8.             } elseif ($event instanceof ConsoleEvent && $app $event->getCommand()->getApplication()) {
  9.                 $output $event->getOutput();
  10.                 if ($output instanceof ConsoleOutputInterface) {
in /home/site/wwwroot/vendor/symfony/error-handler/ErrorHandler.php :: Symfony\Component\HttpKernel\EventListener\{closure} (line 594)
  1.             $this->exceptionHandler null;
  2.         }
  3.         try {
  4.             if (null !== $exceptionHandler) {
  5.                 return $exceptionHandler($exception);
  6.             }
  7.             $handlerException $handlerException ?: $exception;
  8.         } catch (\Throwable $handlerException) {
  9.         }
  10.         if ($exception === $handlerException && null === $this->exceptionHandler) {
ErrorHandler->handleException(object(ErrorException))

Stack Trace

ErrorException

ErrorException:
Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/e4/7f/0b7fe4): failed to open stream: operation failed

  at /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php:175
  at Symfony\Component\HttpKernel\Profiler\FileProfilerStorage->write(object(Profile))
     (/home/site/wwwroot/vendor/symfony/http-kernel/Profiler/Profiler.php:101)
  at Symfony\Component\HttpKernel\Profiler\Profiler->saveProfile(object(Profile))
     (/home/site/wwwroot/vendor/symfony/http-kernel/EventListener/ProfilerListener.php:112)
  at Symfony\Component\HttpKernel\EventListener\ProfilerListener->onKernelTerminate(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/WrappedListener.php:117)
  at Symfony\Component\EventDispatcher\Debug\WrappedListener->__invoke(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php:230)
  at Symfony\Component\EventDispatcher\EventDispatcher->callListeners(array(object(WrappedListener)), 'kernel.terminate', object(TerminateEvent))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php:59)
  at Symfony\Component\EventDispatcher\EventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php:151)
  at Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (/home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php:99)
  at Symfony\Component\HttpKernel\HttpKernel->terminate(object(Request), object(Response))
     (/home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php:116)
  at Symfony\Component\HttpKernel\HttpKernel->terminateWithException(object(ErrorException), object(Request))
     (/home/site/wwwroot/vendor/symfony/http-kernel/EventListener/DebugHandlersListener.php:118)
  at Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::Symfony\Component\HttpKernel\EventListener\{closure}(object(ErrorException))
     (/home/site/wwwroot/vendor/symfony/error-handler/ErrorHandler.php:594)
  at Symfony\Component\ErrorHandler\ErrorHandler->handleException(object(ErrorException))