NUPLAZID® (pimavanserin) logo - once daily - 34 mg capsules
NUPLAZID® (pimavanserin) logo - once daily - 34 mg capsules NUPLAZID® (pimavanserin) logo - once daily - 34 mg capsules

NUPLAZID® is an FDA-approved treatment for hallucinations and delusions associated with Parkinson's disease psychosis.

Support for managing
Parkinson’s
disease–related hallucinations
and delusions 

Connect with a Care Coordinator for medication support

Acadia Connect® logo for patient, caregiver, and healthcare professional support website
Visit Acadia Connect ®
Actor portrayal of smiling woman, an Acadia Connect® Care Coordinator

Committed organizations

These organizations can provide you with more information about the nonmotor symptoms associated with PD.

Logo for The Parkinson’s Foundation

The Parkinson’s Foundation makes life better for people with Parkinson's disease by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience, and passion of our global Parkinson’s community.

Phone: (800) 473-4636
Visit their website
Logo for The American Parkinson Disease Association (APDA)

The American Parkinson Disease Association (APDA) is the largest grassroots network dedicated to fighting PD and works tirelessly to assist those with PD live life to the fullest in the face of this chronic, neurological disorder. APDA provides support nationally through its network of Chapters and Information & Referral (I&R) Centers, as well as a national Research Program and Centers for Advanced Research.

Phone: (800) 223-2732
Visit their website
Logo for The Michael J. Fox Foundation for Parkinson's Research

The Michael J. Fox Foundation is dedicated to finding a cure for Parkinson’s and to ensuring the development of improved therapies for those living with the disease today through an aggressively funded research agenda.

Phone: (800) 708-7644
Visit their website
Logo for The Davis Phinney Foundation for Parkinson's

The Davis Phinney Foundation provides resources and connections that enable people living with Parkinson's to take action that can immediately improve their quality of life. The organization impacts hundreds of thousands of individuals and families each year through community programs, the funding of quality of life research, and extensive online content.

Phone: (866) 358-0285
Visit their website
Logo for Parkinson & Movement Disorder Alliance (PMD Alliance)

Parkinson & Movement Disorder Alliance (PMD Alliance) is a community of movers and motivators working hand-in-hand with those living with a diagnosis, their care partners, adult children, and support group leaders to deliver education and connection to those impacted by movement disorders.

Phone: (800) 256-0966
Visit their website
Back to top
Brain icon representing changes associated with PD-related hallucinations and delusions

PD-related hallucinations and delusions may be more common than you think

Learn more
Icon of a capsule representing NUPLAZID® clinical study and dosing information

See how NUPLAZID can help with PD-related hallucinations and delusions

About NUPLAZID
Safety 
Information
Frequently
 Asked
 Questions

IMPORTANT SAFETY INFORMATION and INDICATION

What is the most important information I should know about NUPLAZID?

  • Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

  • NUPLAZID is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.

Who should not take NUPLAZID?

  • Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath.
  • Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.

What other warnings should I know about NUPLAZID?

  • QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.

    Please also see What is the most important information I should know about NUPLAZID?

What medicine might interact with NUPLAZID?

  • Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first.

What are the common side effects of NUPLAZID?

  • The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088. You can also call Acadia Pharmaceuticals Inc. at 1‑844‑4ACADIA (1‑844‑422‑2342).

Indication

NUPLAZID is a prescription medicine used to treat hallucinations and delusions associated with Parkinson’s disease psychosis.

How should I take NUPLAZID?

The recommended dose of NUPLAZID is one 34 mg capsule once per day, taken by mouth, with or without food.

NUPLAZID is available as 34 mg capsules and 10 mg tablets.

Please read the full Prescribing Information, including Boxed WARNING.

See Safety Information
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Symfony Exception

Symfony Docs
Symfony Support

ErrorException

HTTP 500 Internal Server Error

Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/76/02/6a0276): failed to open stream: operation failed

Exception

ErrorException

in vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php (line 175)
  1.         if (\function_exists('gzcompress')) {
  2.             $file = 'compress.zlib://'.$file;
  3.             stream_context_set_option($context, 'zlib', 'level', 3);
  4.         }
  6.         if (false === file_put_contents($file, serialize($data), 0, $context)) {
  7.             return false;
  8.         }
  10.         if (!$profileIndexed) {
  11.             // Add to index
in vendor/symfony/http-kernel/Profiler/Profiler.php -> write (line 101)
  1.             if ($collector instanceof LateDataCollectorInterface) {
  2.                 $collector->lateCollect();
  3.             }
  4.         }
  6.         if (!($ret = $this->storage->write($profile)) && null !== $this->logger) {
  7.             $this->logger->warning('Unable to store the profiler information.', ['configured_storage' => \get_class($this->storage)]);
  8.         }
  10.         return $ret;
  11.     }
in vendor/symfony/http-kernel/EventListener/ProfilerListener.php -> saveProfile (line 112)
  1.             }
  2.         }
  4.         // save profiles
  5.         foreach ($this->profiles as $request) {
  6.             $this->profiler->saveProfile($this->profiles[$request]);
  7.         }
  9.         $this->profiles = new \SplObjectStorage();
  10.         $this->parents = new \SplObjectStorage();
  11.     }
in vendor/symfony/event-dispatcher/Debug/WrappedListener.php -> onKernelTerminate (line 117)
  1.         $this->called = true;
  2.         $this->priority = $dispatcher->getListenerPriority($eventName, $this->listener);
  4.         $e = $this->stopwatch->start($this->name, 'event_listener');
  6.         ($this->optimizedListener ?? $this->listener)($event, $eventName, $dispatcher);
  8.         if ($e->isStarted()) {
  9.             $e->stop();
  10.         }
in vendor/symfony/event-dispatcher/EventDispatcher.php -> __invoke (line 230)
  2.         foreach ($listeners as $listener) {
  3.             if ($stoppable && $event->isPropagationStopped()) {
  4.                 break;
  5.             }
  6.             $listener($event, $eventName, $this);
  7.         }
  8.     }
  10.     /**
  11.      * Sorts the internal list of listeners for the given event by priority.
in vendor/symfony/event-dispatcher/EventDispatcher.php -> callListeners (line 59)
  1.         } else {
  2.             $listeners = $this->getListeners($eventName);
  3.         }
  5.         if ($listeners) {
  6.             $this->callListeners($listeners, $eventName, $event);
  7.         }
  9.         return $event;
  10.     }
in vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php -> dispatch (line 151)
  1.         try {
  2.             $this->beforeDispatch($eventName, $event);
  3.             try {
  4.                 $e = $this->stopwatch->start($eventName, 'section');
  5.                 try {
  6.                     $this->dispatcher->dispatch($event, $eventName);
  7.                 } finally {
  8.                     if ($e->isStarted()) {
  9.                         $e->stop();
  10.                     }
  11.                 }
in vendor/symfony/http-kernel/HttpKernel.php -> dispatch (line 99)
  1.     /**
  2.      * {@inheritdoc}
  3.      */
  4.     public function terminate(Request $request, Response $response)
  5.     {
  6.         $this->dispatcher->dispatch(new TerminateEvent($this, $request, $response), KernelEvents::TERMINATE);
  7.     }
  9.     /**
  10.      * @internal
  11.      */
in vendor/symfony/http-kernel/Kernel.php -> terminate (line 161)
  1.         if (false === $this->booted) {
  2.             return;
  3.         }
  5.         if ($this->getHttpKernel() instanceof TerminableInterface) {
  6.             $this->getHttpKernel()->terminate($request, $response);
  7.         }
  8.     }
  10.     /**
  11.      * {@inheritdoc}
Kernel->terminate(object(Request), object(Response)) in public/index.php (line 35)
  1.     $kernel = new CacheKernel($kernel);
  2. }
  3. $request = Request::createFromGlobals();
  4. $response = $kernel->handle($request);
  5. $response->send();
  6. $kernel->terminate($request, $response);

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DEBUG 22:14:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onKernelRequest". 
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DEBUG 22:14:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::setDefaultLocale". 
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DEBUG 22:14:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelRequest". 
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DEBUG 22:14:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelRequest". 
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DEBUG 22:14:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleAwareListener::onKernelRequest". 
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DEBUG 22:14:05 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::configureLogoutUrlGenerator". 
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}
DEBUG 22:14:05 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::onKernelRequest". 
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DEBUG 22:14:05 event Notified event "kernel.controller" to listener "Symfony\Bundle\FrameworkBundle\DataCollector\RouterDataCollector::onKernelController". 
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DEBUG 22:14:05 event Notified event "kernel.controller" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelController". 
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DEBUG 22:14:05 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ControllerListener::onKernelController". 
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DEBUG 22:14:05 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ParamConverterListener::onKernelController". 
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DEBUG 22:14:05 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelController". 
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DEBUG 22:14:05 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\SecurityListener::onKernelControllerArguments". 
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INFO 22:14:05 php User Deprecated: getRawData only returns the first dataset loaded, which may not be what you expect. Use getAllRawData() instead which returns all datasets for all autoloaders present in the process. 
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INFO 22:14:05 php User Deprecated: getRawData only returns the first dataset loaded, which may not be what you expect. Use getAllRawData() instead which returns all datasets for all autoloaders present in the process. 
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INFO 22:14:05 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/RPjVeD1QCwqnX7ILJljLG?locale=en-US (0.158s)
DEBUG 22:14:05 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/RPjVeD1QCwqnX7ILJljLG?locale=en-US (0.158s) 
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    "request": "GET /spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/fbccc97f-4a4c-4fe8-beaa-ca8d58c43a0a?locale=en-US HTTP/1.1\r\nHost: cdn.contentful.com\r\nX-Contentful-User-Agent: integration contentful.symfony/6.1.0; sdk contentful.php/6.0.5; platform PHP/7.3.27; os Linux;\r\nAccept: application/vnd.contentful.delivery.v1+json\r\nAccept-Encoding: gzip\r\nAuthorization: Bearer lRzj2SIrbl-UcukRbaRBW6TDRru28Z4mitiO4zneFcQ\r\n\r\n",
    "response": "HTTP/1.1 200 OK\r\nConnection: keep-alive\r\nContent-Length: 592\r\nContent-Type: application/vnd.contentful.delivery.v1+json\r\nX-Contentful-RateLimit-Second-Limit: 150\r\nCF-Space-Id: 5op9sxpwqnmz\r\nCF-Environment-Id: 2.6.2_remove-opt-in\r\nCF-Environment-Uuid: e892f65c-ca0b-48ab-aa26-6627f8bb1bc8\r\nCF-Organization-Id: 6AK7JXzYfDGtxR8WVj1mwu\r\nX-Contentful-Route: /spaces/:space/environments/:environment/entries/:id\r\nETag: \"12939619960788279001\"\r\nX-Content-Type-Options: nosniff\r\nServer: Contentful\r\nX-Contentful-Region: us-east-1\r\nContentful-Api: cda\r\nVia: 1.1 varnish, 1.1 varnish\r\nAccept-Ranges: bytes\r\nAge: 488411\r\nDate: Tue, 04 Aug 2026 22:14:12 GMT\r\nX-Served-By: cache-ewr-kewr1740027-EWR, cache-dfw-kdfw8210156-DFW\r\nX-Cache-Hits: 3, 0\r\naccess-control-allow-headers: accept,accept-language,authorization,cache-control,content-length,content-range,content-type,dnt,destination,expires,if-match,if-modified-since,if-none-match,keep-alive,last-modified,origin,pragma,range,user-agent,x-http-method-override,x-mx-reqtoken,x-requested-with,x-contentful-content-type,x-contentful-enable-alpha-feature,x-contentful-locale-based-publishing,x-contentful-organization,x-contentful-resource-resolution,x-contentful-skip-transformation,x-contentful-user-agent,x-contentful-version\r\naccess-control-allow-methods: GET,HEAD,OPTIONS\r\naccess-control-allow-origin: *\r\naccess-control-max-age: 86400\r\naccess-control-expose-headers: x-contentful-ratelimit-second-limit,x-contentful-ratelimit-reset,etag\r\nstrict-transport-security: max-age=15768000\r\nX-Cache: HIT\r\nx-contentful-request-id: f0eee33f-02b0-4b3d-9d13-93040d8e07e4\r\n\r\n{\"metadata\":{\"tags\":[],\"concepts\":[]},\"sys\":{\"space\":{\"sys\":{\"type\":\"Link\",\"linkType\":\"Space\",\"id\":\"5op9sxpwqnmz\"}},\"id\":\"fbccc97f-4a4c-4fe8-beaa-ca8d58c43a0a\",\"type\":\"Entry\",\"createdAt\":\"2024-10-24T15:05:17.222Z\",\"updatedAt\":\"2024-10-24T15:05:17.222Z\",\"environment\":{\"sys\":{\"id\":\"2.6.2_remove-opt-in\",\"type\":\"Link\",\"linkType\":\"Environment\"}},\"publishedVersion\":1,\"revision\":1,\"contentType\":{\"sys\":{\"type\":\"Link\",\"linkType\":\"ContentType\",\"id\":\"contentItem\"}},\"locale\":\"en-US\"},\"fields\":{\"page\":\"404-page-not-found\",\"content\":\"<a href=\\\"/safety-information\\\">**See Safety Information**</a>\"}}\n",
    "exception": "N;"
}
INFO 22:14:12 security Populated the TokenStorage with an anonymous Token.
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Nelmio\CorsBundle\EventListener\CorsListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Nelmio\\CorsBundle\\EventListener\\CorsListener::onKernelResponse"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Nelmio\CorsBundle\EventListener\CacheableResponseVaryListener::onResponse". 
{
    "event": "kernel.response",
    "listener": "Nelmio\\CorsBundle\\EventListener\\CacheableResponseVaryListener::onResponse"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ResponseListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ResponseListener::onKernelResponse"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\DataCollector\\RequestDataCollector::onKernelResponse"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Symfony\Component\WebLink\EventListener\AddLinkHeaderListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\WebLink\\EventListener\\AddLinkHeaderListener::onKernelResponse"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\HttpCacheListener::onKernelResponse"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Symfony\Component\Security\Http\RememberMe\ResponseListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\Security\\Http\\RememberMe\\ResponseListener::onKernelResponse"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ProfilerListener::onKernelResponse"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ErrorListener::removeCspHeader". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ErrorListener::removeCspHeader"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Symfony\Bundle\WebProfilerBundle\EventListener\WebDebugToolbarListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Bundle\\WebProfilerBundle\\EventListener\\WebDebugToolbarListener::onKernelResponse"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onKernelResponse"
}
DEBUG 22:14:12 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\StreamedResponseListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\StreamedResponseListener::onKernelResponse"
}
DEBUG 22:14:12 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::onKernelFinishRequest"
}
DEBUG 22:14:12 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onFinishRequest"
}
DEBUG 22:14:12 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\RouterListener::onKernelFinishRequest"
}
DEBUG 22:14:12 event Notified event "kernel.finish_request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::onKernelFinishRequest"
}
DEBUG 22:14:12 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleAwareListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleAwareListener::onKernelFinishRequest"
}
DEBUG 22:14:12 event Notified event "kernel.terminate" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelTerminate". 
{
    "event": "kernel.terminate",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ProfilerListener::onKernelTerminate"
}
WARNING 22:14:12 php Uncaught Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/76/02/6a0276): failed to open stream: operation failed 
{
    "exception": {}
}
CRITICAL 22:14:12 request Uncaught PHP Exception ErrorException: "Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/76/02/6a0276): failed to open stream: operation failed" at /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php line 175 
{
    "exception": {}
}
DEBUG 22:14:12 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::configure". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\DebugHandlersListener::configure"
}
DEBUG 22:14:12 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ValidateRequestListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ValidateRequestListener::onKernelRequest"
}
DEBUG 22:14:12 event Notified event "kernel.request" to listener "Nelmio\CorsBundle\EventListener\CorsListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Nelmio\\CorsBundle\\EventListener\\CorsListener::onKernelRequest"
}
DEBUG 22:14:12 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onKernelRequest"
}
DEBUG 22:14:12 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::setDefaultLocale". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::setDefaultLocale"
}
DEBUG 22:14:12 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\RouterListener::onKernelRequest"
}
DEBUG 22:14:12 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::onKernelRequest"
}
DEBUG 22:14:12 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleAwareListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleAwareListener::onKernelRequest"
}
DEBUG 22:14:12 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::configureLogoutUrlGenerator". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::configureLogoutUrlGenerator"
}
DEBUG 22:14:12 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::onKernelRequest"
}
DEBUG 22:14:12 event Notified event "kernel.controller" to listener "Symfony\Bundle\FrameworkBundle\DataCollector\RouterDataCollector::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Symfony\\Bundle\\FrameworkBundle\\DataCollector\\RouterDataCollector::onKernelController"
}
DEBUG 22:14:12 event Notified event "kernel.controller" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Symfony\\Component\\HttpKernel\\DataCollector\\RequestDataCollector::onKernelController"
}
DEBUG 22:14:12 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ControllerListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\ControllerListener::onKernelController"
}
DEBUG 22:14:12 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ParamConverterListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\ParamConverterListener::onKernelController"
}
DEBUG 22:14:12 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\HttpCacheListener::onKernelController"
}
DEBUG 22:14:12 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\TemplateListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\TemplateListener::onKernelController"
}
DEBUG 22:14:12 event Notified event "kernel.controller_arguments" to listener "Symfony\Component\HttpKernel\EventListener\ErrorListener::onControllerArguments". 
{
    "event": "kernel.controller_arguments",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ErrorListener::onControllerArguments"
}
DEBUG 22:14:12 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\SecurityListener::onKernelControllerArguments". 
{
    "event": "kernel.controller_arguments",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\SecurityListener::onKernelControllerArguments"
}
DEBUG 22:14:12 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\IsGrantedListener::onKernelControllerArguments". 
{
    "event": "kernel.controller_arguments",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\IsGrantedListener::onKernelControllerArguments"
}

Stack Trace

ErrorException 

ErrorException:
Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/76/02/6a0276): failed to open stream: operation failed

  at vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php:175
  at Symfony\Component\HttpKernel\Profiler\FileProfilerStorage->write(object(Profile))
     (vendor/symfony/http-kernel/Profiler/Profiler.php:101)
  at Symfony\Component\HttpKernel\Profiler\Profiler->saveProfile(object(Profile))
     (vendor/symfony/http-kernel/EventListener/ProfilerListener.php:112)
  at Symfony\Component\HttpKernel\EventListener\ProfilerListener->onKernelTerminate(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (vendor/symfony/event-dispatcher/Debug/WrappedListener.php:117)
  at Symfony\Component\EventDispatcher\Debug\WrappedListener->__invoke(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (vendor/symfony/event-dispatcher/EventDispatcher.php:230)
  at Symfony\Component\EventDispatcher\EventDispatcher->callListeners(array(object(WrappedListener)), 'kernel.terminate', object(TerminateEvent))
     (vendor/symfony/event-dispatcher/EventDispatcher.php:59)
  at Symfony\Component\EventDispatcher\EventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php:151)
  at Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (vendor/symfony/http-kernel/HttpKernel.php:99)
  at Symfony\Component\HttpKernel\HttpKernel->terminate(object(Request), object(Response))
     (vendor/symfony/http-kernel/Kernel.php:161)
  at Symfony\Component\HttpKernel\Kernel->terminate(object(Request), object(Response))
     (public/index.php:35)
Unable to create the storage directory (/home/site/wwwroot/var/cache/dev/profiler/9d/a4). (500 Internal Server Error)

Symfony Exception

Symfony Docs
Symfony Support

RuntimeException

HTTP 500 Internal Server Error

Unable to create the storage directory (/home/site/wwwroot/var/cache/dev/profiler/9d/a4).

Exception

RuntimeException

in /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php (line 143)
  1.         $profileIndexed = is_file($file);
  2.         if (!$profileIndexed) {
  3.             // Create directory
  4.             $dir = \dirname($file);
  5.             if (!is_dir($dir) && false === @mkdir($dir, 0777, true) && !is_dir($dir)) {
  6.                 throw new \RuntimeException(sprintf('Unable to create the storage directory (%s).', $dir));
  7.             }
  8.         }
  10.         $profileToken = $profile->getToken();
  11.         // when there are errors in sub-requests, the parent and/or children tokens
in /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/Profiler.php -> write (line 101)
  1.             if ($collector instanceof LateDataCollectorInterface) {
  2.                 $collector->lateCollect();
  3.             }
  4.         }
  6.         if (!($ret = $this->storage->write($profile)) && null !== $this->logger) {
  7.             $this->logger->warning('Unable to store the profiler information.', ['configured_storage' => \get_class($this->storage)]);
  8.         }
  10.         return $ret;
  11.     }
in /home/site/wwwroot/vendor/symfony/http-kernel/EventListener/ProfilerListener.php -> saveProfile (line 112)
  1.             }
  2.         }
  4.         // save profiles
  5.         foreach ($this->profiles as $request) {
  6.             $this->profiler->saveProfile($this->profiles[$request]);
  7.         }
  9.         $this->profiles = new \SplObjectStorage();
  10.         $this->parents = new \SplObjectStorage();
  11.     }
in /home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/WrappedListener.php -> onKernelTerminate (line 117)
  1.         $this->called = true;
  2.         $this->priority = $dispatcher->getListenerPriority($eventName, $this->listener);
  4.         $e = $this->stopwatch->start($this->name, 'event_listener');
  6.         ($this->optimizedListener ?? $this->listener)($event, $eventName, $dispatcher);
  8.         if ($e->isStarted()) {
  9.             $e->stop();
  10.         }
in /home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php -> __invoke (line 230)
  2.         foreach ($listeners as $listener) {
  3.             if ($stoppable && $event->isPropagationStopped()) {
  4.                 break;
  5.             }
  6.             $listener($event, $eventName, $this);
  7.         }
  8.     }
  10.     /**
  11.      * Sorts the internal list of listeners for the given event by priority.
in /home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php -> callListeners (line 59)
  1.         } else {
  2.             $listeners = $this->getListeners($eventName);
  3.         }
  5.         if ($listeners) {
  6.             $this->callListeners($listeners, $eventName, $event);
  7.         }
  9.         return $event;
  10.     }
in /home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php -> dispatch (line 151)
  1.         try {
  2.             $this->beforeDispatch($eventName, $event);
  3.             try {
  4.                 $e = $this->stopwatch->start($eventName, 'section');
  5.                 try {
  6.                     $this->dispatcher->dispatch($event, $eventName);
  7.                 } finally {
  8.                     if ($e->isStarted()) {
  9.                         $e->stop();
  10.                     }
  11.                 }
in /home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php -> dispatch (line 99)
  1.     /**
  2.      * {@inheritdoc}
  3.      */
  4.     public function terminate(Request $request, Response $response)
  5.     {
  6.         $this->dispatcher->dispatch(new TerminateEvent($this, $request, $response), KernelEvents::TERMINATE);
  7.     }
  9.     /**
  10.      * @internal
  11.      */
in /home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php -> terminate (line 116)
  1.         $response = $this->handleThrowable($exception, $request, self::MASTER_REQUEST);
  3.         $response->sendHeaders();
  4.         $response->sendContent();
  6.         $this->terminate($request, $response);
  7.     }
  9.     /**
  10.      * Handles a request to convert it to a response.
  11.      *
in /home/site/wwwroot/vendor/symfony/http-kernel/EventListener/DebugHandlersListener.php -> terminateWithException (line 118)
  1.                         if ($hasRun) {
  2.                             throw $e;
  3.                         }
  5.                         $hasRun = true;
  6.                         $kernel->terminateWithException($e, $request);
  7.                     };
  8.                 }
  9.             } elseif ($event instanceof ConsoleEvent && $app = $event->getCommand()->getApplication()) {
  10.                 $output = $event->getOutput();
  11.                 if ($output instanceof ConsoleOutputInterface) {
in /home/site/wwwroot/vendor/symfony/error-handler/ErrorHandler.php :: Symfony\Component\HttpKernel\EventListener\{closure} (line 594)
  1.             $this->exceptionHandler = null;
  2.         }
  4.         try {
  5.             if (null !== $exceptionHandler) {
  6.                 return $exceptionHandler($exception);
  7.             }
  8.             $handlerException = $handlerException ?: $exception;
  9.         } catch (\Throwable $handlerException) {
  10.         }
  11.         if ($exception === $handlerException && null === $this->exceptionHandler) {
ErrorHandler->handleException(object(ErrorException))

Stack Trace

RuntimeException 

RuntimeException:
Unable to create the storage directory (/home/site/wwwroot/var/cache/dev/profiler/9d/a4).

  at /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php:143
  at Symfony\Component\HttpKernel\Profiler\FileProfilerStorage->write(object(Profile))
     (/home/site/wwwroot/vendor/symfony/http-kernel/Profiler/Profiler.php:101)
  at Symfony\Component\HttpKernel\Profiler\Profiler->saveProfile(object(Profile))
     (/home/site/wwwroot/vendor/symfony/http-kernel/EventListener/ProfilerListener.php:112)
  at Symfony\Component\HttpKernel\EventListener\ProfilerListener->onKernelTerminate(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/WrappedListener.php:117)
  at Symfony\Component\EventDispatcher\Debug\WrappedListener->__invoke(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php:230)
  at Symfony\Component\EventDispatcher\EventDispatcher->callListeners(array(object(WrappedListener)), 'kernel.terminate', object(TerminateEvent))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php:59)
  at Symfony\Component\EventDispatcher\EventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php:151)
  at Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (/home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php:99)
  at Symfony\Component\HttpKernel\HttpKernel->terminate(object(Request), object(Response))
     (/home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php:116)
  at Symfony\Component\HttpKernel\HttpKernel->terminateWithException(object(ErrorException), object(Request))
     (/home/site/wwwroot/vendor/symfony/http-kernel/EventListener/DebugHandlersListener.php:118)
  at Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::Symfony\Component\HttpKernel\EventListener\{closure}(object(ErrorException))
     (/home/site/wwwroot/vendor/symfony/error-handler/ErrorHandler.php:594)
  at Symfony\Component\ErrorHandler\ErrorHandler->handleException(object(ErrorException))