NUPLAZID® (pimavanserin) logo - once daily - 34 mg capsules
NUPLAZID® (pimavanserin) logo - once daily - 34 mg capsules NUPLAZID® (pimavanserin) logo - once daily - 34 mg capsules

NUPLAZID® is an FDA-approved treatment for hallucinations and delusions associated with Parkinson's disease psychosis.

NUPLAZID Safety Information FAQs

What is the most important information I should know about NUPLAZID?

  • Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

  • NUPLAZID is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.

Warning sign icon of increased risk of death in elderly patients with dementia-related psychosis

Who should not take NUPLAZID?

Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included:

  • Rash

  • Hives

  • Swelling of the tongue, mouth, lips, or face

  • Throat tightness

  • Shortness of breath

Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.

Icon showing a line across prescription bottle represents warning list of who should not take NUPLAZID®

What warnings should I know about NUPLAZID?

QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.

Please also see What is the most important information I should know about NUPLAZID?

What medicines might interact with NUPLAZID?

Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first.

Medicine bottle icon reflects telling your HCP about all the medicines you take for possible interactions with NUPLAZID®

What are the common side effects of NUPLAZID?

The common side effects of NUPLAZID include:

  • Swelling in the legs or arms

  • Nausea

  • Confusion

  • Hallucination

  • Constipation

  • Changes to normal walking

These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider or pharmacist about this medicine.

Icon of clipboard and question mark reflects a list of the common side effects of NUPLAZID
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treatment with NUPLAZID

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IMPORTANT SAFETY INFORMATION and INDICATION

What is the most important information I should know about NUPLAZID?

  • Medicines like NUPLAZID can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

  • NUPLAZID is not approved for the treatment of patients with dementia who experience psychosis unless their hallucinations and delusions are related to Parkinson’s disease.

Who should not take NUPLAZID?

  • Do not take NUPLAZID if you have had an allergic reaction to any of the ingredients in NUPLAZID. Allergic reactions have included rash, hives, swelling of the tongue, mouth, lips, or face, throat tightness, and shortness of breath.
  • Do not take NUPLAZID if you have certain heart conditions that change your heart rhythm. It is important to talk to your healthcare provider about this possible side effect. Call your healthcare provider if you feel a change in your heartbeat.

What other warnings should I know about NUPLAZID?

  • QT Interval Prolongation: NUPLAZID may increase the risk of changes to your heart rhythm. This risk may increase if NUPLAZID is taken with certain other medications known to prolong the QT interval. Tell your healthcare provider about all the medicines you take or have recently taken.

    Please also see What is the most important information I should know about NUPLAZID?

What medicine might interact with NUPLAZID?

  • Tell your healthcare provider about all the medicines you take. Other medicines may affect how NUPLAZID works. Some medicines should not be taken with NUPLAZID. Your healthcare provider can tell you if it is safe to take NUPLAZID with your other medicines. Do not start or stop any medicines while taking NUPLAZID without talking to your healthcare provider first.

What are the common side effects of NUPLAZID?

  • The common side effects of NUPLAZID include swelling in the legs or arms, nausea, confusion, hallucination, constipation, and changes to normal walking. These are not all the possible side effects of NUPLAZID. For more information, ask your healthcare provider about this medicine.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088. You can also call Acadia Pharmaceuticals Inc. at 1‑844‑4ACADIA (1‑844‑422‑2342).

Indication

NUPLAZID is a prescription medicine used to treat hallucinations and delusions associated with Parkinson’s disease psychosis.

How should I take NUPLAZID?

The recommended dose of NUPLAZID is one 34 mg capsule once per day, taken by mouth, with or without food.

NUPLAZID is available as 34 mg capsules and 10 mg tablets.

Please read the full Prescribing Information, including Boxed WARNING.

Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/8d/9d/6e9d8d): failed to open stream: operation failed (500 Internal Server Error)

Symfony Exception

Symfony Docs
Symfony Support

ErrorException

HTTP 500 Internal Server Error

Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/8d/9d/6e9d8d): failed to open stream: operation failed

Exception

ErrorException

in vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php (line 175)
  1.         if (\function_exists('gzcompress')) {
  2.             $file = 'compress.zlib://'.$file;
  3.             stream_context_set_option($context, 'zlib', 'level', 3);
  4.         }
  6.         if (false === file_put_contents($file, serialize($data), 0, $context)) {
  7.             return false;
  8.         }
  10.         if (!$profileIndexed) {
  11.             // Add to index
in vendor/symfony/http-kernel/Profiler/Profiler.php -> write (line 101)
  1.             if ($collector instanceof LateDataCollectorInterface) {
  2.                 $collector->lateCollect();
  3.             }
  4.         }
  6.         if (!($ret = $this->storage->write($profile)) && null !== $this->logger) {
  7.             $this->logger->warning('Unable to store the profiler information.', ['configured_storage' => \get_class($this->storage)]);
  8.         }
  10.         return $ret;
  11.     }
in vendor/symfony/http-kernel/EventListener/ProfilerListener.php -> saveProfile (line 112)
  1.             }
  2.         }
  4.         // save profiles
  5.         foreach ($this->profiles as $request) {
  6.             $this->profiler->saveProfile($this->profiles[$request]);
  7.         }
  9.         $this->profiles = new \SplObjectStorage();
  10.         $this->parents = new \SplObjectStorage();
  11.     }
in vendor/symfony/event-dispatcher/Debug/WrappedListener.php -> onKernelTerminate (line 117)
  1.         $this->called = true;
  2.         $this->priority = $dispatcher->getListenerPriority($eventName, $this->listener);
  4.         $e = $this->stopwatch->start($this->name, 'event_listener');
  6.         ($this->optimizedListener ?? $this->listener)($event, $eventName, $dispatcher);
  8.         if ($e->isStarted()) {
  9.             $e->stop();
  10.         }
in vendor/symfony/event-dispatcher/EventDispatcher.php -> __invoke (line 230)
  2.         foreach ($listeners as $listener) {
  3.             if ($stoppable && $event->isPropagationStopped()) {
  4.                 break;
  5.             }
  6.             $listener($event, $eventName, $this);
  7.         }
  8.     }
  10.     /**
  11.      * Sorts the internal list of listeners for the given event by priority.
in vendor/symfony/event-dispatcher/EventDispatcher.php -> callListeners (line 59)
  1.         } else {
  2.             $listeners = $this->getListeners($eventName);
  3.         }
  5.         if ($listeners) {
  6.             $this->callListeners($listeners, $eventName, $event);
  7.         }
  9.         return $event;
  10.     }
in vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php -> dispatch (line 151)
  1.         try {
  2.             $this->beforeDispatch($eventName, $event);
  3.             try {
  4.                 $e = $this->stopwatch->start($eventName, 'section');
  5.                 try {
  6.                     $this->dispatcher->dispatch($event, $eventName);
  7.                 } finally {
  8.                     if ($e->isStarted()) {
  9.                         $e->stop();
  10.                     }
  11.                 }
in vendor/symfony/http-kernel/HttpKernel.php -> dispatch (line 99)
  1.     /**
  2.      * {@inheritdoc}
  3.      */
  4.     public function terminate(Request $request, Response $response)
  5.     {
  6.         $this->dispatcher->dispatch(new TerminateEvent($this, $request, $response), KernelEvents::TERMINATE);
  7.     }
  9.     /**
  10.      * @internal
  11.      */
in vendor/symfony/http-kernel/Kernel.php -> terminate (line 161)
  1.         if (false === $this->booted) {
  2.             return;
  3.         }
  5.         if ($this->getHttpKernel() instanceof TerminableInterface) {
  6.             $this->getHttpKernel()->terminate($request, $response);
  7.         }
  8.     }
  10.     /**
  11.      * {@inheritdoc}
Kernel->terminate(object(Request), object(Response)) in public/index.php (line 35)
  1.     $kernel = new CacheKernel($kernel);
  2. }
  3. $request = Request::createFromGlobals();
  4. $response = $kernel->handle($request);
  5. $response->send();
  6. $kernel->terminate($request, $response);

Logs 1

Level Channel Message
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DEBUG 23:55:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ValidateRequestListener::onKernelRequest". 
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DEBUG 23:55:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onKernelRequest". 
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DEBUG 23:55:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::setDefaultLocale". 
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DEBUG 23:55:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelRequest". 
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DEBUG 23:55:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelRequest". 
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DEBUG 23:55:05 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleAwareListener::onKernelRequest". 
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DEBUG 23:55:05 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::configureLogoutUrlGenerator". 
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DEBUG 23:55:05 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::onKernelRequest". 
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DEBUG 23:55:05 event Notified event "kernel.controller" to listener "Symfony\Bundle\FrameworkBundle\DataCollector\RouterDataCollector::onKernelController". 
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}
DEBUG 23:55:05 event Notified event "kernel.controller" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelController". 
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}
DEBUG 23:55:05 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ControllerListener::onKernelController". 
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}
DEBUG 23:55:05 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ParamConverterListener::onKernelController". 
{
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    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\ParamConverterListener::onKernelController"
}
DEBUG 23:55:05 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelController". 
{
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DEBUG 23:55:05 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\TemplateListener::onKernelController". 
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}
DEBUG 23:55:05 event Notified event "kernel.controller_arguments" to listener "Symfony\Component\HttpKernel\EventListener\ErrorListener::onControllerArguments". 
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    "event": "kernel.controller_arguments",
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}
DEBUG 23:55:05 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\SecurityListener::onKernelControllerArguments". 
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}
DEBUG 23:55:05 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\IsGrantedListener::onKernelControllerArguments". 
{
    "event": "kernel.controller_arguments",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\IsGrantedListener::onKernelControllerArguments"
}
INFO 23:55:05 php User Deprecated: getRawData only returns the first dataset loaded, which may not be what you expect. Use getAllRawData() instead which returns all datasets for all autoloaders present in the process. 
{
    "exception": {}
}
INFO 23:55:05 php User Deprecated: getRawData only returns the first dataset loaded, which may not be what you expect. Use getAllRawData() instead which returns all datasets for all autoloaders present in the process. 
{
    "exception": {}
}
INFO 23:55:05 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/RPjVeD1QCwqnX7ILJljLG?locale=en-US (0.134s)
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INFO 23:55:06 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/7MAWwoFWtz8MQqFt6FAkIK?locale=en-US (0.020s)
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DEBUG 23:55:06 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/zxTT5sXraAFNvAVHjgJgv?locale=en-US (0.021s) 
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DEBUG 23:55:06 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/1mTYpwP9s3ZzScQmexs7kr?locale=en-US (0.023s) 
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INFO 23:55:06 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/c114914b-b40f-4e46-a515-35dd44cc3f1a?locale=en-US (0.018s)
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INFO 23:55:06 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/98e54633-efcf-4d06-9c7a-43b8fbd8554a?locale=en-US (0.018s)
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{
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INFO 23:55:06 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/910139d3-619f-432a-a69a-2ba93b043a6a?locale=en-US (0.019s)
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INFO 23:55:06 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/45iK4N3Re0cKDJxg7V2714?locale=en-US (0.021s)
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INFO 23:55:06 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/9babf544-a6d0-4d14-83eb-fabecef6356d?locale=en-US (0.020s)
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INFO 23:55:06 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/ATsnttJxj28YtOcbluXGV?locale=en-US (0.020s)
DEBUG 23:55:06 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/ATsnttJxj28YtOcbluXGV?locale=en-US (0.020s) 
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INFO 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/7cd6d07a-89e4-4545-b732-53f591428b93?locale=en-US (0.024s)
DEBUG 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/7cd6d07a-89e4-4545-b732-53f591428b93?locale=en-US (0.024s) 
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INFO 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/ed1719e3-9685-45f8-8a24-8304e232348e?locale=en-US (0.020s)
DEBUG 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/ed1719e3-9685-45f8-8a24-8304e232348e?locale=en-US (0.020s) 
{
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    "request": "GET /spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/ed1719e3-9685-45f8-8a24-8304e232348e?locale=en-US HTTP/1.1\r\nHost: cdn.contentful.com\r\nX-Contentful-User-Agent: integration contentful.symfony/6.1.0; sdk contentful.php/6.0.5; platform PHP/7.3.27; os Linux;\r\nAccept: application/vnd.contentful.delivery.v1+json\r\nAccept-Encoding: gzip\r\nAuthorization: Bearer lRzj2SIrbl-UcukRbaRBW6TDRru28Z4mitiO4zneFcQ\r\n\r\n",
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INFO 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/31d18885-f2a9-47c7-8bfe-e7be843c6cb5?locale=en-US (0.019s)
DEBUG 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/31d18885-f2a9-47c7-8bfe-e7be843c6cb5?locale=en-US (0.019s) 
{
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INFO 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/795afa38-572d-4cb7-9a06-ea0ab59db44e?locale=en-US (0.020s)
DEBUG 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/795afa38-572d-4cb7-9a06-ea0ab59db44e?locale=en-US (0.020s) 
{
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    "request": "GET /spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/795afa38-572d-4cb7-9a06-ea0ab59db44e?locale=en-US HTTP/1.1\r\nHost: cdn.contentful.com\r\nX-Contentful-User-Agent: integration contentful.symfony/6.1.0; sdk contentful.php/6.0.5; platform PHP/7.3.27; os Linux;\r\nAccept: application/vnd.contentful.delivery.v1+json\r\nAccept-Encoding: gzip\r\nAuthorization: Bearer lRzj2SIrbl-UcukRbaRBW6TDRru28Z4mitiO4zneFcQ\r\n\r\n",
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INFO 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/8U7fcj1IUBwx3QRk9h96a?locale=en-US (0.020s)
DEBUG 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/8U7fcj1IUBwx3QRk9h96a?locale=en-US (0.020s) 
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INFO 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/23b9796d-03b2-41e3-8e4e-44192a131fc2?locale=en-US (0.028s)
DEBUG 23:55:07 app GET https://cdn.contentful.com/spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/23b9796d-03b2-41e3-8e4e-44192a131fc2?locale=en-US (0.028s) 
{
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    "duration": 0.028059959411621094,
    "request": "GET /spaces/5op9sxpwqnmz/environments/2.6.2_remove-opt-in/entries/23b9796d-03b2-41e3-8e4e-44192a131fc2?locale=en-US HTTP/1.1\r\nHost: cdn.contentful.com\r\nX-Contentful-User-Agent: integration contentful.symfony/6.1.0; sdk contentful.php/6.0.5; platform PHP/7.3.27; os Linux;\r\nAccept: application/vnd.contentful.delivery.v1+json\r\nAccept-Encoding: gzip\r\nAuthorization: Bearer lRzj2SIrbl-UcukRbaRBW6TDRru28Z4mitiO4zneFcQ\r\n\r\n",
    "response": "HTTP/1.1 200 OK\r\nConnection: keep-alive\r\nContent-Length: 595\r\nserver-timing: total;dur=9\r\naccess-control-allow-methods: GET,HEAD,OPTIONS\r\ncontent-type: application/vnd.contentful.delivery.v1+json\r\nserver: Contentful\r\naccess-control-allow-headers: Accept,Accept-Language,Authorization,Cache-Control,Content-Length,Content-Range,Content-Type,Destination,Dnt,Expires,If-Match,If-Modified-Since,If-None-Match,Keep-Alive,Last-Modified,Origin,Pragma,Range,User-Agent,X-Contentful-Content-Type,X-Contentful-Enable-Alpha-Feature,X-Contentful-Extensions-Sourcemap,X-Contentful-Locale-Based-Publishing,X-Contentful-Organization,X-Contentful-Personal-Intercept,X-Contentful-Resource-Resolution,X-Contentful-Skip-Transformation,X-Contentful-User-Agent,X-Contentful-Version,X-Http-Method-Override,X-Mx-Reqtoken,X-Requested-With\r\nx-contentful-ratelimit-second-limit: 150\r\naccess-control-allow-origin: *\r\naccess-control-max-age: 86400\r\ncf-environment-uuid: e892f65c-ca0b-48ab-aa26-6627f8bb1bc8\r\naccess-control-expose-headers: Etag\r\ncontentful-api: cda\r\nx-contentful-request-id: 3c83e449-a277-483e-937e-56016491a1c7\r\netag: \"11543160015497312453\"\r\nstrict-transport-security: max-age=31536000\r\nx-content-type-options: nosniff\r\nage: 357296\r\nx-cache: HIT\r\nx-served-by: cache-dfw-kdal2120056-DFW\r\ndate: Sun, 18 Oct 2026 23:55:07 GMT\r\n\r\n{\"metadata\":{\"tags\":[],\"concepts\":[]},\"sys\":{\"space\":{\"sys\":{\"type\":\"Link\",\"linkType\":\"Space\",\"id\":\"5op9sxpwqnmz\"}},\"id\":\"23b9796d-03b2-41e3-8e4e-44192a131fc2\",\"type\":\"Entry\",\"createdAt\":\"2024-10-24T15:05:16.846Z\",\"updatedAt\":\"2024-10-24T15:05:16.846Z\",\"environment\":{\"sys\":{\"id\":\"2.6.2_remove-opt-in\",\"type\":\"Link\",\"linkType\":\"Environment\"}},\"publishedVersion\":1,\"revision\":1,\"contentType\":{\"sys\":{\"type\":\"Link\",\"linkType\":\"ContentType\",\"id\":\"contentItem\"}},\"locale\":\"en-US\"},\"fields\":{\"page\":\"404-page-not-found\",\"content\":\"<p>12830 El Camino Real, Suite 400<br />\\nSan Diego, CA 92130</p>\"}}\n",
    "exception": "N;"
}
INFO 23:55:07 security Populated the TokenStorage with an anonymous Token.
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Nelmio\CorsBundle\EventListener\CorsListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Nelmio\\CorsBundle\\EventListener\\CorsListener::onKernelResponse"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Nelmio\CorsBundle\EventListener\CacheableResponseVaryListener::onResponse". 
{
    "event": "kernel.response",
    "listener": "Nelmio\\CorsBundle\\EventListener\\CacheableResponseVaryListener::onResponse"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ResponseListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ResponseListener::onKernelResponse"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\DataCollector\\RequestDataCollector::onKernelResponse"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Symfony\Component\WebLink\EventListener\AddLinkHeaderListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\WebLink\\EventListener\\AddLinkHeaderListener::onKernelResponse"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\HttpCacheListener::onKernelResponse"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Symfony\Component\Security\Http\RememberMe\ResponseListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\Security\\Http\\RememberMe\\ResponseListener::onKernelResponse"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ProfilerListener::onKernelResponse"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\ErrorListener::removeCspHeader". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ErrorListener::removeCspHeader"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Symfony\Bundle\WebProfilerBundle\EventListener\WebDebugToolbarListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Bundle\\WebProfilerBundle\\EventListener\\WebDebugToolbarListener::onKernelResponse"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onKernelResponse"
}
DEBUG 23:55:07 event Notified event "kernel.response" to listener "Symfony\Component\HttpKernel\EventListener\StreamedResponseListener::onKernelResponse". 
{
    "event": "kernel.response",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\StreamedResponseListener::onKernelResponse"
}
DEBUG 23:55:07 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::onKernelFinishRequest"
}
DEBUG 23:55:07 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onFinishRequest"
}
DEBUG 23:55:07 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\RouterListener::onKernelFinishRequest"
}
DEBUG 23:55:07 event Notified event "kernel.finish_request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::onKernelFinishRequest"
}
DEBUG 23:55:07 event Notified event "kernel.finish_request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleAwareListener::onKernelFinishRequest". 
{
    "event": "kernel.finish_request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleAwareListener::onKernelFinishRequest"
}
DEBUG 23:55:07 event Notified event "kernel.terminate" to listener "Symfony\Component\HttpKernel\EventListener\ProfilerListener::onKernelTerminate". 
{
    "event": "kernel.terminate",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ProfilerListener::onKernelTerminate"
}
WARNING 23:55:07 php Uncaught Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/8d/9d/6e9d8d): failed to open stream: operation failed 
{
    "exception": {}
}
CRITICAL 23:55:07 request Uncaught PHP Exception ErrorException: "Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/8d/9d/6e9d8d): failed to open stream: operation failed" at /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php line 175 
{
    "exception": {}
}
DEBUG 23:55:07 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::configure". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\DebugHandlersListener::configure"
}
DEBUG 23:55:07 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\ValidateRequestListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ValidateRequestListener::onKernelRequest"
}
DEBUG 23:55:07 event Notified event "kernel.request" to listener "Nelmio\CorsBundle\EventListener\CorsListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Nelmio\\CorsBundle\\EventListener\\CorsListener::onKernelRequest"
}
DEBUG 23:55:07 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\SessionListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\SessionListener::onKernelRequest"
}
DEBUG 23:55:07 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::setDefaultLocale". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::setDefaultLocale"
}
DEBUG 23:55:07 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\RouterListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\RouterListener::onKernelRequest"
}
DEBUG 23:55:07 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleListener::onKernelRequest"
}
DEBUG 23:55:07 event Notified event "kernel.request" to listener "Symfony\Component\HttpKernel\EventListener\LocaleAwareListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\LocaleAwareListener::onKernelRequest"
}
DEBUG 23:55:07 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::configureLogoutUrlGenerator". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::configureLogoutUrlGenerator"
}
DEBUG 23:55:07 event Notified event "kernel.request" to listener "Symfony\Bundle\SecurityBundle\Debug\TraceableFirewallListener::onKernelRequest". 
{
    "event": "kernel.request",
    "listener": "Symfony\\Bundle\\SecurityBundle\\Debug\\TraceableFirewallListener::onKernelRequest"
}
DEBUG 23:55:08 event Notified event "kernel.controller" to listener "Symfony\Bundle\FrameworkBundle\DataCollector\RouterDataCollector::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Symfony\\Bundle\\FrameworkBundle\\DataCollector\\RouterDataCollector::onKernelController"
}
DEBUG 23:55:08 event Notified event "kernel.controller" to listener "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Symfony\\Component\\HttpKernel\\DataCollector\\RequestDataCollector::onKernelController"
}
DEBUG 23:55:08 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ControllerListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\ControllerListener::onKernelController"
}
DEBUG 23:55:08 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\ParamConverterListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\ParamConverterListener::onKernelController"
}
DEBUG 23:55:08 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\HttpCacheListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\HttpCacheListener::onKernelController"
}
DEBUG 23:55:08 event Notified event "kernel.controller" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\TemplateListener::onKernelController". 
{
    "event": "kernel.controller",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\TemplateListener::onKernelController"
}
DEBUG 23:55:08 event Notified event "kernel.controller_arguments" to listener "Symfony\Component\HttpKernel\EventListener\ErrorListener::onControllerArguments". 
{
    "event": "kernel.controller_arguments",
    "listener": "Symfony\\Component\\HttpKernel\\EventListener\\ErrorListener::onControllerArguments"
}
DEBUG 23:55:08 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\SecurityListener::onKernelControllerArguments". 
{
    "event": "kernel.controller_arguments",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\SecurityListener::onKernelControllerArguments"
}
DEBUG 23:55:08 event Notified event "kernel.controller_arguments" to listener "Sensio\Bundle\FrameworkExtraBundle\EventListener\IsGrantedListener::onKernelControllerArguments". 
{
    "event": "kernel.controller_arguments",
    "listener": "Sensio\\Bundle\\FrameworkExtraBundle\\EventListener\\IsGrantedListener::onKernelControllerArguments"
}

Stack Trace

ErrorException 

ErrorException:
Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/8d/9d/6e9d8d): failed to open stream: operation failed

  at vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php:175
  at Symfony\Component\HttpKernel\Profiler\FileProfilerStorage->write(object(Profile))
     (vendor/symfony/http-kernel/Profiler/Profiler.php:101)
  at Symfony\Component\HttpKernel\Profiler\Profiler->saveProfile(object(Profile))
     (vendor/symfony/http-kernel/EventListener/ProfilerListener.php:112)
  at Symfony\Component\HttpKernel\EventListener\ProfilerListener->onKernelTerminate(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (vendor/symfony/event-dispatcher/Debug/WrappedListener.php:117)
  at Symfony\Component\EventDispatcher\Debug\WrappedListener->__invoke(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (vendor/symfony/event-dispatcher/EventDispatcher.php:230)
  at Symfony\Component\EventDispatcher\EventDispatcher->callListeners(array(object(WrappedListener)), 'kernel.terminate', object(TerminateEvent))
     (vendor/symfony/event-dispatcher/EventDispatcher.php:59)
  at Symfony\Component\EventDispatcher\EventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php:151)
  at Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (vendor/symfony/http-kernel/HttpKernel.php:99)
  at Symfony\Component\HttpKernel\HttpKernel->terminate(object(Request), object(Response))
     (vendor/symfony/http-kernel/Kernel.php:161)
  at Symfony\Component\HttpKernel\Kernel->terminate(object(Request), object(Response))
     (public/index.php:35)
Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/e3/25/6525e3): failed to open stream: operation failed (500 Internal Server Error)

Symfony Exception

Symfony Docs
Symfony Support

ErrorException

HTTP 500 Internal Server Error

Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/e3/25/6525e3): failed to open stream: operation failed

Exception

ErrorException

in /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php (line 175)
  1.         if (\function_exists('gzcompress')) {
  2.             $file = 'compress.zlib://'.$file;
  3.             stream_context_set_option($context, 'zlib', 'level', 3);
  4.         }
  6.         if (false === file_put_contents($file, serialize($data), 0, $context)) {
  7.             return false;
  8.         }
  10.         if (!$profileIndexed) {
  11.             // Add to index
in /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/Profiler.php -> write (line 101)
  1.             if ($collector instanceof LateDataCollectorInterface) {
  2.                 $collector->lateCollect();
  3.             }
  4.         }
  6.         if (!($ret = $this->storage->write($profile)) && null !== $this->logger) {
  7.             $this->logger->warning('Unable to store the profiler information.', ['configured_storage' => \get_class($this->storage)]);
  8.         }
  10.         return $ret;
  11.     }
in /home/site/wwwroot/vendor/symfony/http-kernel/EventListener/ProfilerListener.php -> saveProfile (line 112)
  1.             }
  2.         }
  4.         // save profiles
  5.         foreach ($this->profiles as $request) {
  6.             $this->profiler->saveProfile($this->profiles[$request]);
  7.         }
  9.         $this->profiles = new \SplObjectStorage();
  10.         $this->parents = new \SplObjectStorage();
  11.     }
in /home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/WrappedListener.php -> onKernelTerminate (line 117)
  1.         $this->called = true;
  2.         $this->priority = $dispatcher->getListenerPriority($eventName, $this->listener);
  4.         $e = $this->stopwatch->start($this->name, 'event_listener');
  6.         ($this->optimizedListener ?? $this->listener)($event, $eventName, $dispatcher);
  8.         if ($e->isStarted()) {
  9.             $e->stop();
  10.         }
in /home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php -> __invoke (line 230)
  2.         foreach ($listeners as $listener) {
  3.             if ($stoppable && $event->isPropagationStopped()) {
  4.                 break;
  5.             }
  6.             $listener($event, $eventName, $this);
  7.         }
  8.     }
  10.     /**
  11.      * Sorts the internal list of listeners for the given event by priority.
in /home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php -> callListeners (line 59)
  1.         } else {
  2.             $listeners = $this->getListeners($eventName);
  3.         }
  5.         if ($listeners) {
  6.             $this->callListeners($listeners, $eventName, $event);
  7.         }
  9.         return $event;
  10.     }
in /home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php -> dispatch (line 151)
  1.         try {
  2.             $this->beforeDispatch($eventName, $event);
  3.             try {
  4.                 $e = $this->stopwatch->start($eventName, 'section');
  5.                 try {
  6.                     $this->dispatcher->dispatch($event, $eventName);
  7.                 } finally {
  8.                     if ($e->isStarted()) {
  9.                         $e->stop();
  10.                     }
  11.                 }
in /home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php -> dispatch (line 99)
  1.     /**
  2.      * {@inheritdoc}
  3.      */
  4.     public function terminate(Request $request, Response $response)
  5.     {
  6.         $this->dispatcher->dispatch(new TerminateEvent($this, $request, $response), KernelEvents::TERMINATE);
  7.     }
  9.     /**
  10.      * @internal
  11.      */
in /home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php -> terminate (line 116)
  1.         $response = $this->handleThrowable($exception, $request, self::MASTER_REQUEST);
  3.         $response->sendHeaders();
  4.         $response->sendContent();
  6.         $this->terminate($request, $response);
  7.     }
  9.     /**
  10.      * Handles a request to convert it to a response.
  11.      *
in /home/site/wwwroot/vendor/symfony/http-kernel/EventListener/DebugHandlersListener.php -> terminateWithException (line 118)
  1.                         if ($hasRun) {
  2.                             throw $e;
  3.                         }
  5.                         $hasRun = true;
  6.                         $kernel->terminateWithException($e, $request);
  7.                     };
  8.                 }
  9.             } elseif ($event instanceof ConsoleEvent && $app = $event->getCommand()->getApplication()) {
  10.                 $output = $event->getOutput();
  11.                 if ($output instanceof ConsoleOutputInterface) {
in /home/site/wwwroot/vendor/symfony/error-handler/ErrorHandler.php :: Symfony\Component\HttpKernel\EventListener\{closure} (line 594)
  1.             $this->exceptionHandler = null;
  2.         }
  4.         try {
  5.             if (null !== $exceptionHandler) {
  6.                 return $exceptionHandler($exception);
  7.             }
  8.             $handlerException = $handlerException ?: $exception;
  9.         } catch (\Throwable $handlerException) {
  10.         }
  11.         if ($exception === $handlerException && null === $this->exceptionHandler) {
ErrorHandler->handleException(object(ErrorException))

Stack Trace

ErrorException 

ErrorException:
Warning: file_put_contents(compress.zlib:///home/site/wwwroot/var/cache/dev/profiler/e3/25/6525e3): failed to open stream: operation failed

  at /home/site/wwwroot/vendor/symfony/http-kernel/Profiler/FileProfilerStorage.php:175
  at Symfony\Component\HttpKernel\Profiler\FileProfilerStorage->write(object(Profile))
     (/home/site/wwwroot/vendor/symfony/http-kernel/Profiler/Profiler.php:101)
  at Symfony\Component\HttpKernel\Profiler\Profiler->saveProfile(object(Profile))
     (/home/site/wwwroot/vendor/symfony/http-kernel/EventListener/ProfilerListener.php:112)
  at Symfony\Component\HttpKernel\EventListener\ProfilerListener->onKernelTerminate(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/WrappedListener.php:117)
  at Symfony\Component\EventDispatcher\Debug\WrappedListener->__invoke(object(TerminateEvent), 'kernel.terminate', object(TraceableEventDispatcher))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php:230)
  at Symfony\Component\EventDispatcher\EventDispatcher->callListeners(array(object(WrappedListener)), 'kernel.terminate', object(TerminateEvent))
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/EventDispatcher.php:59)
  at Symfony\Component\EventDispatcher\EventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (/home/site/wwwroot/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php:151)
  at Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher->dispatch(object(TerminateEvent), 'kernel.terminate')
     (/home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php:99)
  at Symfony\Component\HttpKernel\HttpKernel->terminate(object(Request), object(Response))
     (/home/site/wwwroot/vendor/symfony/http-kernel/HttpKernel.php:116)
  at Symfony\Component\HttpKernel\HttpKernel->terminateWithException(object(ErrorException), object(Request))
     (/home/site/wwwroot/vendor/symfony/http-kernel/EventListener/DebugHandlersListener.php:118)
  at Symfony\Component\HttpKernel\EventListener\DebugHandlersListener::Symfony\Component\HttpKernel\EventListener\{closure}(object(ErrorException))
     (/home/site/wwwroot/vendor/symfony/error-handler/ErrorHandler.php:594)
  at Symfony\Component\ErrorHandler\ErrorHandler->handleException(object(ErrorException))